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Table 4 Treatment and outcome of seven patients with mixed cryoglobulinemic glomerulonephritis associated with HBV infection

From: Clinicopathological study of mixed cryoglobulinemic glomerulonephritis secondary to hepatitis B virus infection

Case

Anti-viral

Immunosuppressive therapy

Follow-up time (months)

Scr (μmol/L)

eGFR (ml/min per 1.73m2)

24hUP (g/d)

Cryocrit(%)

HBV-DNA (copies/ml)

Outcome

1

ETV

CS + MMF

37

90

67.00

0.80

NA

< 103

PR

2

ETV

CS + CYC + DFPP

22

99

55.30

2.05

7.0

< 103

PR

3

ETV

CS + CYC + DFPP

6

60

111.80

0.05

0

< 103

CR

4

LAM

CS + CYC

3

119

54.13

3.77

NA

NA

death

5

ETV

CS

62

80

114.00

0.90

2.0

1.24 × 104

PR

6

ETV

CS

12

287

20.70

5.22

NA

NA

death

7

ETV

CS + CYC

18

900

5.50

9.92

0

< 103

dialysis

  1. Scr Serum creatinine, eGFR Estimated glomerular filtration rate, 24hUP 24-h urine protein, ETV Entecavir, LAM Lamivudine, CS Corticosteroid, MMF Mycophenolate, CYC Cyclophosphamide, DFPP Double-filtration plasmapheresis, CR Complete remission, PR Partial remission, NA Not available