Fig. 2
From: Protective effects of DPP-4 inhibitor on podocyte injury in glomerular diseases
DPP-4 activity in DN with or without DPP-4 inhibitor. a Partial podocytes, nodular lesion (arrow head), and proximal tubules were stained with DPP-4 in a patient with DN without DPP-4 inhibitor treatment (w/o DPP-4 inhibitor). Renal DPP-4 activity was suppressed by DPP-4 inhibitor, compared to the case not treated with DPP-4 inhibitor. b DPP-4 positive area was significantly high in FSGS, ANCA-RN and DN w/o DPP-4 inhibitor treatment, compared to minor glomerular abnormality. DPP-4 activity in the glomeruli was significantly suppressed by treatment with DPP-4 inhibitor. *: P < 0.05, ***: P < 0.001