Table 1 Participant Baseline Demographic and Clinical Characteristics
From: Symptom-burden in people living with frailty and chronic kidney disease
|  | Non-Frail (n = 128) | Frail (n = 225) | Unadjusted P Value |
|---|---|---|---|
Age (years), mean (SE) | 71.5 (0.9) | 77.7 (0.6) | < 0.001* |
Female, n (%) | 70 (55) | 130 (58) | Â |
Current or ex-smoker, n (%) | 57 (45) | 125 (56) | Â |
University/college qualification, n (%) | 43 (34) | 57 (25) | Â |
Self-reported health problems, n (%) | |||
 - Diabetes | 13 (10) | 45 (20) |  |
 - Heart | 19 (15) | 84 (37) |  |
 - Stroke | 6 (5) | 32 (14) |  |
 - Blood vessels or circulation | 19 (15) | 66 (29) |  |
 - Lung or breathing | 17 (13) | 64 (28) |  |
 - Liver | 7 (5) | 16 (7) |  |
 - Joints, bones or muscles | 52 (41) | 161 (72) |  |
 - Mental health | 14 (11) | 37 (16) |  |
Chronic kidney disease stage, n (%) | |||
 - CKD G2 | 14 (11) | 17 (8) |  |
 - CKD G3a | 87 (68) | 123 (55) |  |
 - CKD G3b | 26 (20) | 68 (30) |  |
 - CKD G4 | 1 (1) | 17 (8) |  |
Laboratory Variables, mean (SE) | |||
 - eGFR (mL/min/1.73m2) | 50.9 (0.7) | 45.8 (0.7) | < 0.001* |
 - Haemoglobin (g/L) | 137.4 (1.7) | 132.2 (1.1) | 0.01 |
 - Albumin (g/L) | 41.4 (0.5) | 39.2 (0.4) | < 0.001* |
Frailty Components, n (%) | |||
 - Weakness/slowness | 12 (9) | 179 (80) |  |
 - Exhaustion | 41 (32) | 208 (92) |  |
 - Low physical activity | 32 (25) | 172 (76) |  |
Slow walking pace, n (%) | 11 (9) | 130 (58) | Â |
VO2 Peak mL/kg/min, mean (SE) | 33.9 (6.0) | 21.7 (9.1) | < 0.001* |
Total symptoms, mean (SE) | 6.9 (0.3) | 9.2 (0.1) | < 0.001* |
Total symptom score, mean (SE) | 14.6 (0.7) | 24.9 (0.6) | < 0.001* |
SF-12 PCS, mean (SE) | 51.8 (0.6) | 36.4 (0.7) | < 0.001* |
SF-12 MCS, mean (SE) | 53.8 (0.7) | 50.2 (0.7) | < 0.001* |