Table 2 Patient’s autoimmune panel results
Investigation | Result |
|---|---|
Autoimmune Screen | |
Complement 3 | 0.76 g/L (0.74–1.57) repeated 12 h later 0.62 g/L |
Complement 4 | 0.08 g/L (0.13–0.41) initial, repeated after 2 days normal 0.17 g/L |
Complement 9 | 500 mg/L (125–165) |
Complement 5–8 | Normal range |
Complement Factor H antibody | < 8 (< 100 AU) |
CD46 | 1.27 (1.75–4.65 MFI) Crossed checked twice with a health control |
Complement Factor H | 581 mg/L (345–590 mg/L) |
Complement Factor B | 450 mg/L (normal) |
Anti-DsDNA Antibodies | Negative |
Anti-Nuclear Antibodies | |
RNP Antibodies | |
Lupus Anticoagulant | |
B2-Glycoprotein | |
Anti-Smith Antibodies | |
SSA and SSB Antibodies | |
Ro 52 Antibodies | |
Scleroderma Ab | |
Jo-1 Antibodies | |
Haemolytic Screen | |
Reticulocytes | 150 × 10^9/L (50–100 × 10^9/L) |
Haptoglobin | < 0.15 (0.3–2.5 g/L) |
ADAMTS13 Activity | 70% (40–130%; normal) |
Blood Film | Red cell fragments (1 per high power field). Mild polychromasia. Toxic granulation of neutrophils. Moderate thrombocytopenia. |
Direct Antiglobulin Test | Negative |
Methylenetetrahydrofolate reductase protein | Negative gene analysis |
Factor V Leiden mutation | Not Detected |
The Prothrombin gene mutation | Not Detected |
Coagulopathy | |
INR | 1.8 (< 1) Corrected with mixing study |
PT | 19 s (11–18 s) Corrected with mixing study |
APTT | 56 s (24–38 s) Corrected with mixing study |
Protein C Activity | 52% (70–180%) |
Protein S Activity | 39% (55–190%) |
Infection Screen | |
Toxoplasmosis | IgM and IgG Negative |
CMV and Parvovirus | IgG positive. IgM negative. |
Hepatitis B and C | Negative HCV core antibody and RNA/ Immune HBV surface antibody positive antigens negative |