Table 3 Characteristics of kidney transplant recipients with COVID-19
From: The COVID-19 nephrology compendium: AKI, CKD, ESKD and transplantation
Study | N | Female, % | Median age, years | Median Transplant age, years | Maintenance IS | AKI incidence, % | RRT, % | Mechanical Ventilation, % | Mortality, % | Salient Findings |
|---|---|---|---|---|---|---|---|---|---|---|
Banerjee [92] | 7 | 42 | 54 | 2 | FK + M + S - 4 FK + M - 1 AZA + S - 2 | 57 | 43 | 14 | 14 | 2 patients presented within 3 months of transplantation; 6 had cessation of anti-metabolites. |
Nair [85] | 10 | 40 | 57 | 7.7 | FK + M + S [7] FK + M [2] | 50 | 10 | 40 | 30 | 8 had cessation of MMF/MPA. All treated with HCQ and AZT. |
Columbia [93] | 15 | 30 | 51 | 4 | FK - 14 M - 12 S - 10 B - 2 AZA - 1 Leflunomide - 1 | 40 | 14 | 27 | 7 | 10/14 had cessation of anti-metabolite; 13 received HCQ +/− AZT (6 still hospitalized at the time of publication). |
Alberici [89] | 20 | 20 | 59 | 13 | FK - 19 M - 14 S - 13 mTORi - 2 | 30 | 5 | 0 | 25 | All patients had their usual transplant immunosuppression withdrawn and started methylprednisolone 16 mg or equivalent dose of prednisone, and 19/20 received antiviral therapy and HCQ; 6 patients treated with tocilizumab. |
Akalin [94] | 36 | 28 | 60 | NR | FK - 35 M - 21 S - 34 | NR | 21 | 39 | 28 | Withdrawal of an antimetabolite in 24/28 patients (86%). FK was also withheld in 6/28 severely ill patients (21%). HCQ was administered to 24/ 28 patients (86%). Two recent KTRs who had received ATG within the previous 5 weeks died. |
Lubetsky [96] | 54 | 30 | 57 | 4.7 | FK- 52 M-52 S- 20 | 51 | 10 | 28 | 13 | None of the ambulatory patients had tacrolimus reduction or discontinuation of MMF |
Cravedi [95] | 144 | 35 | 62 | 5 | FK - 131 M - 111 S - 125 mTORi - 11 | 52 | NR | 30 | 32 | Non-survivors were older, had lower lymphocyte counts and eGFR, higher serum LDH, procalcitonin and IL-6 levels. |
Caillard [97] | 279 | 35 | 62 | 5 | CNI- 230 M- 211 AZA- 16 S- 202 mTORi- 34 B- 16 | 44 | 11 | 30 | 23 | High BMI, fever, and dyspnea were independent risk factors for severe Covid-19 in this patient group, whereas age > 60 years, cardiovascular disease, and dyspnea were independently associated with mortality. |
Elias [98] Outcomes for patients with COVID-19 reported | 1216 (66 patients with COVID-19) | 36 | 54 | NR | CNI- 57 M/AZA- 61 B- 6 S- 55 | 42 | 11 | 22 | 24 | Factors that were independently associated with COVID-19 in- cluded non-White race and comorbidities, including obesity, di- abetes, and asthma and chronic pulmonary disease. |