Table 5 List of therapeutic abortions and congenital malformations identified among 25 offspring of male kidney transplant recipients exposed to immunosuppressive medication
From: Paternity in male kidney transplant recipients: a French national survey, the PATeRNAL study
Therapeutic abortion, n = 12 | ||||
Year of pregnancy | Year of transplant | Paternal agea | Medical reason for abortion | Male KT recipients’ medication regimen at the time of conception |
1986 | 1981 | NA | Genetic disorder | AZA, prednisone |
NA | 1994 | NA | Trisomy 21 | MMF/MPA, tacrolimus, prednisone |
2005 | 1979 | 31 | Spina bifida and Arnold Chiari | AZA, prednisone |
2012 | 2006 | 48 | Ectopic pregnancy | MMF/MPA, cyclosporine |
2013 | 2007 | 34 | Trisomy 21 | MMF/MPA, cyclosporine |
2014 | 2010 | 36 | missing | MMF/MPA, tacrolimus, prednisone |
2015 | 2006 | 34 | missing | MMF/MPA, tacrolimus, prednisone |
2016 | 2009 | 40 | missing | MMF/MPA, tacrolimus, prednisone |
2016 | 2008 | 35 | missing | Tacrolimus, prednisone |
2016 | 2011 | 35 | Multiple malformations | Tacrolimus, everolimus, prednisone |
2018 | 2014 | 33 | missing | MMF/MPA, tacrolimus, prednisone |
2018 | 2013 | 43 | missing | MMF/MPA, tacrolimus, prednisone |
Congenital malformation, n = 13 | ||||
Year of birth | Year of transplant | Paternal agea | Congenital malformation | Male KT recipients’ medication regimen at the time of conception |
1998 | 1996 | 33 | Cleft lip and palate | AZA, cyclosporine |
2000 | NA | NA | Deafness | AZA, cyclosporine, prednisone |
2001 | 1998 | 32 | Congenital phimosis | MMF/MPA, cyclosporine, tacrolimus, prednisone |
2001 | 2000 | NA | Cleft lip and palate | AZA, tacrolimus, prednisone |
2002 | 1989 | 41 | Complex cardio-facial syndrome | AZA, tacrolimus, prednisone |
2005 | 2004 | 34 | Left thumb’s agenesis | MMF/MPA, tacrolimus, prednisone |
2006 | 1992 | 25 | Pyloric stenosis | MMF/MPA, tacrolimus, prednisone |
2009 | 2007 | 21 | Renal hypoplasia | MMF/MPA, tacrolimus |
2012 | 2007 | 30 | Hypospadias | MMF/MPA, cyclosporine |
2015 | 2011 | 26 | Hypoplastic toes | MMF/MPA, tacrolimus, prednisone |
2015 | 2013 | 32 | Urinary tract malformation | MMF/MPA, tacrolimus |
2016 | 2010 | 32 | Plagiocephaly | MMF/MPA, tacrolimus, prednisone |
2017 | 2006 | 38 | Wolff Parkinson White syndrome | MMF/MPA, tacrolimus, prednisone |