Table 2 Clinical characteristics of 5 recipients with ongoing donor-transmitted diabetic kidney disease

 Sex

Female

Male

Male

Male

Female

 VAge in years

32.8

44.2

52.7

27.5

43.6

 Pre-transplant dialysis

HD

HD

HD

HD

HD

 Years on dialysis

11.4

6.8

3.7

3.7

5.0

 Cause of ESRD

GN

Unknown

Analgesic

SLE

Unknown

 BMI at transplant (kg/m²)

27.5

24.9

24.6

20.3

21.1

 Anti-HCV (+) recipient

N

N

N

N

N

 Post-transplant diabetes mellitus

N

N

N

N

N

 BMI at follow-up biopsy (kg/m²)

25.9

26.7

23.7

28.0

20.0

 Weight change (kg) after transplantation

−4.5

+ 4.6

−2.3

+ 24.9

−2.7

 Dyslipidemia at follow-up biopsy

Y

Y

Y

Y

Y

 Hypertension at follow-up biopsy

Y

Y

Y

Y

Y

 HbA1c before transplantation (%)

5.3

5.2

5.5

5.2

5.4

 HbA1c after transplantation (%)

5.3

5.8

5.7

5.9

5.9

 Last UPCR after transplantation (mg/mg)

11.626

5.379

1.980

0.849

10.03

 Best eGFR after transplantation (ml/min/1.73m²)

40.33

57.79

42.16

143.78

44.30

 Last eGFR after transplantation (ml/min/1.73m²)

14.16

11.51

9.28

39.71

5.4

 eGFR decline rate (ml/min/1.73m²/year)

8.72

6.77

10.86

14.87

10.30

 Duration of follow-up in years

3.7

7.4

3.2

7.5

4.0

 Allograft biopsy RPS DN classification

IIa → IIb → III^a

III

III

IIb → III^a

IIb → III → IV^a

 Number of indication follow-up biopsies

5

4

2

4

3

 (post-transplant months/DN classification)

0.2/IIa

10.7/ III

18.5/ III

20.6/IIb

10.2/IIb

 (post-transplant months/DN classification)

0.6/IIa

21.2/ III

36.0/ III

62.9/III

20.1/III

 (post-transplant months/DN classification)

3.5/IIa

61.7/ III

79.5/III

34.8/IV

 (post-transplant months/DN classification)

13.9/IIb

65.5/ III

83.2/III

 (post-transplant months/DN classification)

26.4/III

 Graft failure

N

N

N

N

Y

 Donor age in years

39

57

57

22

44

 Body mass index at transplant (kg/m²)

26.0

28.2

28.2

27.7

22.9

 Creatinine at transplant (mg/dl)

2.8

2.5

2.5

0.5

0.8

 eGFR at transplant (ml/min/1.73m²)

26.95

28.44

28.44

163.98

111.62

 Last HbA1c before transplantation (%)

8.0

7.0

7.0

7.1

6.3

 Anti-HCV (+) donor

N

N

N

N

N

 Expanded criteria donor

N

Y

Y

N

N

 Zero-time biopsy RPS DN classification

IIa

IIb

IIb

Nil

Nil

 PRA≧30%

N

N

N

N

Y

 ≧1 HLA mismatch

Y

Y

Y

N

Y

 Delayed graft function

Y

N

N

N

Y

 Acute rejection within 1 year

Y

N

N

N

Y

 Tacrolimus + MMF/MPA + steroid maintenance

Y

Y

Y

Y

Y

 No induction

N

N

N

Y

N

 Lymphodepleting induction

Y

N

N

N

N

 Non-lymphodepleting induction

N

Y

Y

N

Y