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Table 1 Main clinical and laboratory characteristics at baseline in patients with IgAN

From: Effect of hydroxychloroquine in patients with IgA nephropathy with insufficient responses to immunosuppressive therapy: a retrospective case-control study

  IS therapy plus HCQ
N = 26
Conventional IS therapy
N = 26
P-value
Gender
 Male/female 9/17 10/16 0.773
 Age at renal biopsy (years) 28.8 ± 10.2 30.8 ± 12.2 0.522
 Duration of IS therapy before HCQ/other IS agents (months) 7.4 (4.9,10.8) 3.9 (2.1,11.3) 0.079
 Proteinuria level before IS therapy (g/d) 2.52 (1.66,5.60) 2.27 (1.54,4.36) 0.727
 Baseline proteinuria (g/d) 2.35 (1.47,2.98) 2.35 (1.54,2.98) 0.920
 Baseline eGFR (ml/min/1.73 m2) 47.65 (34.65,67.48) 51.59 (26.47,82.32) 0.855
Oxford Classification
 M 0/1 2/21 9/17 0.030
 E 0/1 11/12 14/12 0.674
 S 0/1 7/16 15/11 0.056
 T 0/1/2 3/18/2 11/11/4 0.034
 C 0/1/2 5/15/3 10/16/0 0.104
 RAASi therapy 25 22  
 ACEI alone 14 4  
 ARB alone 11 6  
 ACEI plus ARB 0 12  
 Use of statins 6 8  
Corticosteroid treatment
 Corticosteroid pulse therapy 13 8  
 Oral corticosteroids 13 18  
 Immunosuppressive agents 14/26 26/26  
 Cyclophosphamide 6 14  
 Mycophenolate mofetil 3 3  
 Cyclosporine A 2 4  
 Leflunomide 2 4  
 FK506 1 1  
  1. The histological scores of 3 patients in the group “IS therapy plus HCQ” were unavailable because they underwent renal biopsy in other clinics
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