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Table 1 Main clinical and laboratory characteristics at baseline in patients with IgAN

From: Effect of hydroxychloroquine in patients with IgA nephropathy with insufficient responses to immunosuppressive therapy: a retrospective case-control study

 

IS therapy plus HCQ

N = 26

Conventional IS therapy

N = 26

P-value

Gender

 Male/female

9/17

10/16

0.773

 Age at renal biopsy (years)

28.8 ± 10.2

30.8 ± 12.2

0.522

 Duration of IS therapy before HCQ/other IS agents (months)

7.4 (4.9,10.8)

3.9 (2.1,11.3)

0.079

 Proteinuria level before IS therapy (g/d)

2.52 (1.66,5.60)

2.27 (1.54,4.36)

0.727

 Baseline proteinuria (g/d)

2.35 (1.47,2.98)

2.35 (1.54,2.98)

0.920

 Baseline eGFR (ml/min/1.73 m2)

47.65 (34.65,67.48)

51.59 (26.47,82.32)

0.855

Oxford Classification

 M 0/1

2/21

9/17

0.030

 E 0/1

11/12

14/12

0.674

 S 0/1

7/16

15/11

0.056

 T 0/1/2

3/18/2

11/11/4

0.034

 C 0/1/2

5/15/3

10/16/0

0.104

 RAASi therapy

25

22

 

 ACEI alone

14

4

 

 ARB alone

11

6

 

 ACEI plus ARB

0

12

 

 Use of statins

6

8

 

Corticosteroid treatment

 Corticosteroid pulse therapy

13

8

 

 Oral corticosteroids

13

18

 

 Immunosuppressive agents

14/26

26/26

 

 Cyclophosphamide

6

14

 

 Mycophenolate mofetil

3

3

 

 Cyclosporine A

2

4

 

 Leflunomide

2

4

 

 FK506

1

1

 
  1. The histological scores of 3 patients in the group “IS therapy plus HCQ” were unavailable because they underwent renal biopsy in other clinics