Elevated alanine aminotransferase and low aspartate aminotransferase/alanine aminotransferase ratio are associated with chronic kidney disease among middle-aged women: a cross-sectional study

Table 4 Association of combination of low AST/ALT ratio (AST/ALT ratio < 1) and elevated GGT (GGT > 50 U/L) with CKD

	Total N	CKD n (%)	Crude	Adjusted
	Total N	CKD n (%)	OR (95% CI)	OR (95% CI)
AST/ALT ratio < 1 and GGT > 50 U/L	1380	255 (18.5)	2.73 (2.36–3.15)	1.87 (1.60–2.18)
AST/ALT ratio < 1 and GGT ≤ 50 U/L	4153	510 (12.3)	1.68 (1.52–1.87)	1.36 (1.21–1.52)
AST/ALT ratio ≥ 1 and GGT > 50 U/L	1157	188 (16.3)	2.33 (1.98–2.75)	1.57 (1.32–1.86)
AST/ALT ratio ≥ 1 and GGT ≤ 50 U/L	22,443	1724 (7.7)	1.00	1.00

ALT Alanine aminotransferase, AST Aspartate aminotransferase, GGT Gamma-glutamyltransferase
CKD Chronic kidney disease, OR Odds ratio, CI Confidence interval
Adjusted for age, smoking status (none, former or current), alcohol intake (none, sometimes or everyday), obesity, hypertension, dyslipidemia, and diabetes

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