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Fig. 5 | BMC Nephrology

Fig. 5

From: Constitutive Atg5 overexpression in mouse bone marrow endothelial progenitor cells improves experimental acute kidney injury

Fig. 5

Endothelial-to-mesenchymal transition. Comparably to the fibrosis patterns, only one group (‘IRI 6 w’) showed different aSMA abundances in CD31+ cells. EPC treatment, either performed with native or transfected cells, did not modulate endothelial aSMA in a significant manner. Image d magnifies the surrounded (white rectangular) area in c. The white circle in d surrounds the borderzone between media (musculature - green) and intima, predominantely represented by the endothelial layer (red). The yellow indicates aSMA expression by CD31+ cells (magnifications in b and c: × 40, in d × 160; Data in a as mean +/− SEM; *: p-value between ‘Control 6 w’ and ‘IRI 6 w’ < 0.05)

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