Table 2 Clinical differences in pediatric CKD patients with and without left ventricular diastolic dysfunction
Variable | Patients with left ventricular diastolic dysfunction (n = 11) | Patients without left ventricular diastolic dysfunction (n = 233) | P value |
|---|---|---|---|
Age, median (full range) | 7.6 (0.5–13.0) | 11.4 (0.3–17.9) | 0.037 |
Male/Female | 6/5 | 162/71 | 0.325 |
Chronic kidney disease stage | |||
 I | 4 (36.4) | 41 (17.6) |  |
 II | 3 (27.3) | 44 (18.9) |  |
 III | 2 (18.2) | 83 (35.6) |  |
 IV | 2 (18.2) | 43 (18.5) |  |
 V | – | 22 (9.4) |  |
Height Z-score | −1.2 ± 1.0 | −0.8 ± 1.6 | 0.445 |
Weight Z-score | −1.1 ± 1.1 | −0.8 ± 1.8 | 0.332 |
Body mass index Z-score | −0.3 ± 1.2 | −0.3 ± 1.4 | 0.861 |
Estimated glomerular filtration rate (ml/min/1.73 m2) | 76.7 ± 46.0 | 56.5 ± 37.7 | 0.117 |
Hypertension | 6 (66.7) | 151 (71.6) | 0.718 |
Hemoglobin (g/dL) | 11.1 ± 1.8 | 12.4 ± 1.8 | 0.015 |
Transferrin Saturation (%) | 27.6 ± 21.1 | 27.8 ± 13.0 | 0.589 |
Serum albumin (g/dL) | 4.1 ± 0.4 | 4.1 ± 0.6 | 0.353 |
Serum Ca (mg/dL) | 9.2 ± 0.5 | 9.5 ± 0.7 | 0.062 |
Serum P (mg/dL) | 4.8 ± 0.5 | 4.8 ± 0.9 | 0.944 |
Ca x P (mg2/dL2) | 43.9 ± 5.4 | 45.5 ± 8.5 | 0.456 |
Serum tCO2 (mmol/L) | 23.3 ± 3.8 | 22.5 ± 3.5 | 0.715 |
Total cholesterol (mg/dL) | 154.3 ± 20.7 | 184.5 ± 70.4 | 0.054 |
Serum low-density lipoprotein cholesterol (mg/dL) | 95.0 ± 17.2 | 106.1 ± 63.5 | 0.888 |
Serum high-density lipoprotein cholesterol (mg/dL) | 46.3 ± 11.9 | 54.4 ± 15.0 | 0.077 |
Serum triglyceride (mg/dL) | 108.6 ± 37.5 | 153.5 ± 158.9 | 0.347 |
Intact parathyroid hormone (pg/mL) | 49.8 (17.1–243.0) | 55.3 (5.8–1244.0) | 0.926 |
25 (OH) vitamin D3 (ng/mL) | 26.0 ± 17.3 | 21.1 ± 9.2 | 0.452 |
Tubular reabsorption of phosphate (%) | 90.5 ± 8.3 | 77.6 ± 13.7 | 0.009 |
Left ventricular mass index (g/m2.7) | 48.8 ± 14.9 | 36.5 ± 12.7 | 0.002 |
left ventricular wall thickness z-score | 1.4 ± 3.7 | −3.1 ± 6.3 | 0.008 |