Variable | Coefficient | 95% confidence interval | p-value |
|---|
Lower | Upper |
|---|
Female sex | −0.89 | −1.36 | −0.42 | < 0.0001 |
Glomerular diseasesa | −0.95 | − 1.47 | − 0.44 | < 0.0001 |
Ethnicity (cf. White) |
 Asian | 0.41 | −0.31 | 1.14 | 0.3 |
 Black | −1.52 | −2.67 | −0.38 | 0.009 |
 Mixed/Other | 0.42 | −0.88 | 1.71 | 0.5 |
First reported eGFR post-transplantb (cf. < 60 mL/min/1.73m2) |
 60–90 | −0.56 | −1.05 | −0.07 | 0.03 |
  > 90 | −3.55 | −4.37 | −2.72 | < 0.0001 |
Age groupc (cf. 25–29 years) |
 2–4 | −1.73 | −3.47 | 0.01 | 0.05 |
 5–9 | −0.07 | −1.16 | 1.01 | 0.9 |
 10–14 | −0.23 | −1.12 | 0.66 | 0.6 |
 15–19 | −1.27 | − 1.99 | −0.54 | 0.001 |
 20–24 | −1.45 | −2.11 | −0.80 | < 0.0001 |
 30–34 | 0.70 | −0.07 | 1.47 | 0.08 |
 35–39 | 1.18 | −0.04 | 2.40 | 0.06 |
 40–44 | 2.07 | −0.54 | 4.67 | 0.1 |
- aPrimary kidney disease was using a 2012 European coding system [52]. The pediatric diagnosis was used where discordant between pediatric and adult databases [28]
- beGFR post-transplant calculated from the first biochemical data recorded by the UK Renal Registry following transplantation. Returns are annual for paediatrics and quarterly for adults. There was evidence of non-linearity between initial eGFR and eGFR decline and therefore data are presented as categorical
- cAge at start of eGFR slope analysis. Age range grouped into 5-year bands, however there were no transplants under the age of 2 years
- The regression coefficient of the model intercept was −1.54 (95% CI, − 2.08 to − 1.00; p < 0.0001)
- There were no interactions between: sex and primary kidney disease, sex and initial eGFR or primary kidney disease and ethnicity. There was a significant interaction (likelihood ratio test p < 0.0001 between full model and model fitting the interaction term) between initial eGFR and ethnicity. The stratum-specific exposure effects of initial eGFR and ethnicity (compared with White, eGFR < 60 mL/min/1.73 m2) are as follows:
- Asian, eGFR 60–90 0.11 (95% CI -1.45, 1.66), p = 0.9
- Asian, eGFR > 90 -0.49 (95% CI -2.73, 1.76), p = 0.7
- Black, eGFR 60–90 0.30 (95% CI -2.17, 2.77), p = 0.8
- Black, eGFR > 90 -9.00 (95% CI -12.6, − 5.44), p < 0.0001
- Mixed/Other, eGFR 60–90 -0.34 (95% CI -3.08, 2.40), p = 0.8
- Mixed/Other, eGFR > 90 -2.25 (95% CI -6.55, 2.05), p = 0.3
