| Â | Total AKI | Established AKI | Later-on AKI |
|---|
| Â | AUC ROC | 95%CI | Cutoff | P | AUC ROC | 95%CI | Cutoff | P | AUC ROC | 95%CI | Cutoff | P |
|---|
Before matching |
 Total | 0.769 ± 0.011 | 0.753–0.785 | 1.00 | < 0.001 | 0.810 ± 0.017 | 0.793–0.826 | 0.93 | < 0.001 | 0.748 ± 0.014 | 0.730–0.765 | 1.02 | < 0.001 |
 Group I | 0.769 ± 0.012 | 0.752–0.786 | 1.00 | < 0.001 | 0.810 ± 0.018 | 0.793–0.827 | 0.93 | < 0.001 | 0.747 ± 0.015 | 0.729–0.765 | 1.02 | < 0.001 |
 Group II | 0.733 ± 0.060 | 0.613–0.831 | 1.00 | < 0.001 | 0.760 ± 0.086 | 0.622–0.868 | 1.04 | 0.003 | 0.714 ± 0.072 | 0.580–0.825 | 1.00 | 0.003 |
 Group III | 0.736 ± 0.064 | 0.609–0.840 | 1.21 | < 0.001 | 0.781 ± 0.085 | 0.631–0.891 | 1.48 | 0.001 | 0.712 ± 0.078 | 0.569–0.829 | 1.09 | 0.007 |
 Group IV | 0.724 ± 0.061 | 0.629–0.805 | 1.36 | < 0.001 | 0.779 ± 0.077 | 0.676–0.862 | 0.99 | < 0.001 | 0.707 ± 0.074 | 0.608–0.793 | 1.64 | 0.005 |
After matching |
 Total | 0.758 ± 0.015 | 0.733–0.782 | 1.09 | < 0.001 | 0.802 ± 0.021 | 0.775–0.827 | 0.98 | < 0.001 | 0.732 ± 0.019 | 0.704–0.759 | 1.09 | < 0.001 |
 Group I | 0.768 ± 0.017 | 0.740–0.794 | 0.95 | < 0.001 | 0.812 ± 0.023 | 0.782–0.839 | 0.98 | < 0.001 | 0.740 ± 0.021 | 0.709–0.770 | 0.95 | < 0.001 |
 Group II | 0.733 ± 0.060 | 0.613–0.831 | 1.00 | < 0.001 | 0.760 ± 0.086 | 0.622–0.868 | 1.04 | 0.003 | 0.714 ± 0.072 | 0.580–0.825 | 1.00 | 0.003 |
 Group III | 0.736 ± 0.064 | 0.609–0.840 | 1.21 | < 0.001 | 0.781 ± 0.085 | 0.631–0.891 | 1.48 | 0.001 | 0.712 ± 0.078 | 0.569–0.829 | 1.09 | 0.007 |
 Group IV | 0.724 ± 0.061 | 0.629–0.805 | 1.36 | < 0.001 | 0.779 ± 0.077 | 0.676–0.862 | 0.99 | < 0.001 | 0.707 ± 0.074 | 0.608–0.793 | 1.64 | 0.005 |
- 95% CI 95% Confidence interval; AKI Acute kidney injury; AUC-ROC Area under the receiver operating characteristic curve; ICU Intensive care unit; KDIGO Kidney Disease: Improving Global Outcomes; Established AKI, defined as diagnosis of AKI at ICU admission; Later-onset AKI, indicated no AKI diagnosis at ICU admission but reaching the KDIGO criteria within 1 week after admission;
- Grouping of standards was according to cumulative doses of glucocorticoids within 5 days before admission to ICU: Group I: non-users; Group II: 0 mg < prednisone ≤50 mg; Group III: 50 mg < prednisone ≤150 mg; Group IV: prednisone > 150 mg;
- Before matching: Total AKI: AUC of Group I vs. AUC of Group II, Z = 0.588, P = 0.556. AUC of Group I vs. AUC of Group III, Z = 0.507, P = 0.612. AUC of Group I vs. AUC of Group IV, Z = 0.724, P = 0.469. AUC of Group II vs. AUC of Group III, Z = −0.034, P = 0.973. AUC of Group II vs. AUC of Group IV, Z = 0.105, P = 0.916. AUC of Group III vs. AUC of Group IV, Z = 0.136, P = 0.892. Established AKI: AUC of Group I vs. AUC of Group II, Z = 0.569, P = 0.569. AUC of Group I vs. AUC of Group III, Z = 0.334, P = 0.739. AUC of Group I vs. AUC of Group IV, Z = 0.392, P = 0.695. AUC of Group II vs. AUC of Group III, Z = − 0.174, P = 0.862. AUC of Group II vs. AUC of Group IV, Z = − 0.165, P = 0.869. AUC of Group III vs. AUC of Group IV, Z = 0.017, P = 0.986. Later-on AKI: AUC of Group I vs. AUC of Group II, Z = 0.449, P = 0.654. AUC of Group I vs. AUC of Group III, Z = 0.441, P = 0.660. AUC of Group I vs. AUC of Group IV, Z = 0.530, P = 0.596. AUC of Group II vs. AUC of Group III, Z = 0.019, P = 0.985. AUC of Group II vs. AUC of Group IV, Z = 0.068, P = 0.946. AUC of Group III vs. AUC of Group IV, Z = 0.047, P = 0.963
- After matching: Total AKI: AUC of Group I vs. AUC of Group II, Z = 0.561, P = 0.575. AUC of Group I vs. AUC of Group III, Z = 0.483, P = 0.629. AUC of Group I vs. AUC of Group IV, Z = 0.695, P = 0.487. AUC of Group II vs. AUC of Group III, Z = − 0.034, P = 0.973. AUC of Group II vs. AUC of Group IV, Z = 0.105, P = 0.916. AUC of Group III vs. AUC of Group IV, Z = 0.136, P = 0.892. Established AKI: AUC of Group I vs. AUC of Group II, Z = 0.584, P = 0.559. AUC of Group I vs. AUC of Group III, Z = 0.352, P = 0.725. AUC of Group I vs. AUC of Group IV, Z = 0.411, P = 0.681. AUC of Group II vs. AUC of Group III, Z = − 0.174, P = 0.862. AUC of Group II vs. AUC of Group IV, Z = − 0.165, P = 0.869. AUC of Group III vs. AUC of Group IV, Z = 0.017, P = 0.986. Later-on AKI: AUC of Group I vs. AUC of Group II, Z = 0.347, P = 0.729. AUC of Group I vs. AUC of Group III, Z = 0.347, P = 0.729. AUC of Group I vs. AUC of Group IV, Z = 0.429, P = 0.668. AUC of Group II vs. AUC of Group III, Z = 0.019, P = 0.985. AUC of Group II vs. AUC of Group IV, Z = 0.068, P = 0.946. AUC of Group III vs. AUC of Group IV, Z = 0.047, P = 0.963
