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Fig. 4 | BMC Nephrology

Fig. 4

From: Significance of kidney biopsy in autosomal dominant tubulointerstitial kidney disease-UMOD: is kidney biopsy truly nonspecific?

Fig. 4

Immunofluorescence staining images using anti-UMOD Ab of ADTKD-UMOD patients cases #1-#13 and a control kidney. In all except two patients: a son and a father (cases #12 and #13) who share the same C94F UMOD mutations, UMOD proteins lost their original localization pattern, namely were scattered throughout the cytoplasm and collected around the tubular lumina. In their kidneys, UMOD proteins irregularly accumulate and make strong signals. In kidneys of ADTKD-UMOD patients with C94F mutations (#12 and #13), atrophy of UMOD positive TAL cells was marked. However the patterns of UMOD localization did not differ from those of normal kidney

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