Fig. 4
Effect of CSE/H2S system on TGF-β protein expression and Smad3 phosphorylation. Representative results of Western blot demonstrated the changes in TGF-β protein expression and Smad3 phosphorylation levels in the sham, UAAS, UAAS+NaHS and UAAS+PPG groups (a, c); Quantitative analysis (b, d) showed that TGF-β protein expression and Smad3 phosphorylation levels decreased significantly in UAAS mice, but NaHS treatment attenuated the UAAS-induced inhibition on TGF-β protein expression and Smad3 phosphorylation levels, and PPG treatment aggravated the decrease of TGF-β protein expression and Smad3 phosphorylation levels (*P < 0.05 vs. sham group, #P < 0.05 vs. UAAS group, and &P < 0.05 vs. UAAS group, n = 6 per group)