Baseline liver function tests and full blood count indices and their association with progression of chronic kidney disease and renal outcomes in Aboriginal and Torres Strait Islander people: the eGFR follow- up study

Table 3 Cox regression models of association of measures of concentrations of liver function tests and full blood count indices with renal outcomes

Baseline measure	Crude		Adjusted for age and gender		Adjusted for age, gender and UACR		Adjusted for age gender, UACR and diabetes		Adjusted for age, gender, UACR, diabetes, CRP, total cholesterol, triglycerides, BMI, WHR, Alcohol consumption
Baseline measure	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Log ALT (U/L)	0.58 (0.35–0.94)	0.027	0.67 (0.40–1.12)	0.129	0.64 (0.37–1.10)	0.109	0.54 (0.31–0.98)	0.041	0.64 (0.35–1.17)	0.147
Log GTT (U/L)	1.48 (1.10–2.00)	0.012	1.49 (1.10–2.02)	0.011	1.53 (1.10–2.13)	0.011	1.54 (1.08–2.16)	0.017	1.55 (1.13–2.14)	0.004
Log ALP (U/L)	11.38 (5.88–22.01)	< 0.001	13.40 (6.68–27.23)	< 0.001	9.35 (4.40–19.86)	< 0.001	7.56 (3.55–16.08)	< 0.001	4.95 (2.32–10.52)	< 0.001
Log Bilirubin (μmol/L)	0.42 (0.26–0.68)	< 0.001	0.35 (0.21–0.57)	< 0.001	0.52 (0.31–0.89)	0.016	0.49 (0.28–0.87)	0.015	0.62 (0.35–1.08)	0.011
Albumin (g/l)	0.87 (0.84–0.90)	< 0.001	0.88 (0.84–0.91)	< 0.001	N/A	N/A	0.86 (0.81–0.91)^a	< 0.001	0.84 (0.79–0.90)^a	< 0.001
WBC (×10⁹/L)	1.07 (0.99–1.15)	0.108	1.07 (1.00–1.15)	0.044	1.05 (0.97–1.14)	0.219	1.05 (0.97–1.13)	0.245	1.05 (0.96–1.13)	0.283
RBC (×10¹²/L)	0.93 (0.82–1.05)	0.237	0.94 (0.82–1.08)	0.392	0.96 (0.83–1.10)	0.545	0.96 (0.83–1.10)	0.535	0.96 (0.82–1.13)	0.622
Haemoglobin (g/L)	0.96 (0.95–0.97)	< 0.001	0.95 (0.94–0.97)	< 0.001	0.95 (0.94–0.97)	< 0.001	0.95 (0.94–0.97)	< 0.001	0.96 (0.94–0.98)	< 0.001

^aUACR not include in the model
HR Hazard Ratio, 95% CI 95% Confidence Intervals, ALT Alanine Aminotransferase, GGT Gamma-glutamyl transferase, ALP Alkaline phosphatase, UACR Urine albumin/creatinine ratio, U/L units per litre, g/L grams per litre, μmol/L micromoles per litre, cholesterol mmol/L, triglycerides mmol/L, C-reactive protein mg/L, BMI body mass index, WHR waist hip ratio

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