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Table 3 CKD-MBD parameters and phosphate binder pill burden at baseline and during sucroferric oxyhydroxide follow-up (Q1 to Q4) in the overall study cohort (N = 1096)

From: The real-world effectiveness of sucroferric oxyhydroxide in European hemodialysis patients: a 1-year retrospective database analysis

Parameter

Baseline

(N = 1089)

Q1

(N = 968)

Q2

(N = 738)

Q3

(N = 536)

Q4

(N = 378)

Serum phosphate, mmol/L

1.88 ± 0.36

1.77 ± 0.41***

1.70 ± 0.40***

1.70 ± 0.42***

1.69 ± 0.42***

Serum PTH, pmol/L

47.5 ± 46.7

48.8 ± 46.0

48.4 ± 47.2

50.6 ± 52.7

52.1 ± 51.8

Serum calcium, mmol/L

2.24 ± 0.16

2.23 ± 0.17*

2.24 ± 0.17

2.24 ± 0.17

2.24 ± 0.16

Total phosphate binder pill consumption, pills/day

6.3 ± 9.0

5.1 ± 7.6

5.0 ± 5.4

5.3 ± 5.6

5.2 ± 5.5

SFOH pill consumption, pills/day

N/A

2.3 ± 1.4

2.5 ± 1.5

2.6 ± 1.5

2.6 ± 1.5

SFOH dose, mg/day

N/A

1172 ± 718

1236 ± 773

1285 ± 770

1308 ± 765

Number of patients receiving cinacalcet, n (%)

355 (32.6)

357 (36.9)

267 (36.2)

200 (37.3)

148 (39.2)

Number of patients receiving vitamin D analogs, n (%)

426 (39.1)

372 (38.4)

293 (39.7)

223 (41.6)

158 (41.8)

  1. *p < 0.05; ***p < 0.0001 (vs baseline)
  2. All values are mean ± SD unless otherwise specified
  3. Abbreviations: CKD-MBD chronic kidney disease-bone and mineral disorder, PTH parathyroid hormone, N/A not applicable, SD standard deviation, SFOH sucroferric oxyhydroxide