Skip to main content
Fig. 7 | BMC Nephrology

Fig. 7

From: Immunohistochemical study for the expression of leukocyte adhesion molecules, and FGF23 and ACE2 in P. gingivalis LPS-induced diabetic nephropathy

Fig. 7

Prediction of complex etiology of P. gingivalis LPS-induced diabetic nephropathy. Severe periodontitis causes bacteremia and microorganisms of the oral cavity enter kidneys through the systemic circulation. AGE induces renal TLR expression, recognized by TLR2/4, and promotes the expression of cytokines and leukocyte adhesion molecule VCAM-1, and E-selectin. Inflammatory infiltration of Mac-1/podoplanin positive macrophages causes with overexpression of leukocyte adhesion molecules in P. gingivalis LPS-accumulated renal glomeruli, and simultaneously ACE2 overexpression and bone-derived FGF23 accumulation promote tubulitis and diabetic nephropathy with hypertensive renal diseases

Back to article page

BMC Nephrology

ISSN: 1471-2369

Contact us