Table 2 Histologic Characteristics of biopsies included in this study
PMN (n = 41) | LN-V (n = 19) | DN (n = 28) | p-value | Total | |
|---|---|---|---|---|---|
Number of glomeruli per view (n [IQR]) | 15 (10–21) | 16 (8–20) | 16 (10–26) | 0.47 | 15 (10–23) |
Sclerosed glomeruli (n) | 0.0 (0.0-6.7) | 0.0 (0.0-2.6) | 22.5 (8.4–48.7) | 0.001 | 0.0 (0.0-14.8) |
Tubular atrophy [n (%)] | 7 (17.1) | 4 (21.1) | 18 (64.3) | < 0.001 | 29 (32.9) |
Interstitial fibrosis [n (%)] | 12 (29.3) | 7 (36.8) | 26 (92.9) | < 0.001 | 45 (51.1) |
Immunohistochemistry: | |||||
• IgG [n (%)] | 31 (75.6) | 16 (84.2) | 4 (14.3) | < 0.001 | 51 (57.9) |
• IgA [n (%)] | 9 (21.9) | 7 (36.8) | 1 (3.6) | 0.02 | 17 (19.3) |
• IgM [n (%)] | 16 (39.0) | 13 (68.4) | 8 (28.6) | 0.02 | 37 (42.1) |
• C3 [n (%)] | 31 (75.6) | 10 (52.6) | 7 (25.0) | < 0.001 | 48 (54.5) |
PLA2R (positive) | 21 (51.2) | 0 (0.0) | 0 (0.0) | < 0.001 | 21 (23.9) |
THSD7A (positive) | 2 (4.9) | 0 (0.0) | 0 (0.0) | 0.31 | 2 (2.3) |