Endothelial glycocalyx damage in kidney disease correlates with uraemic toxins and endothelial dysfunction

BMC Nephrology

Table 3 Regression analyses of log-hyaluronan

Variables	Univariable coefficient β (95% CI)	p-value	R²	Multivariable coefficient β (95% CI)	p-value
Age	0.03 (0.02 to 0.04)	<0.001	0.41	0.028 (0.02 to 0.04)	<0.001
eGFR^b	-0.01 (-0.01 to -0.003)	0.003	0.09
SBP	0.02 (0.02 to 0.03)	<0.001	0.19
BMI	0.03 (-0.009 to 0.06)	0.01	0.05
Patient group^a			0.36
CKD	1.13 (0.75 to 1.50)	<0.001		0.30 (-0.14 to 0.73)	0.18
Dialysis	1.52 (1.15 to 1.90)	<0.001		0.87 (0.46 to 1.26)	<0.001
Transplant	0.77 (0.38 to 1.15)	<0.001		0.33 (-0.04 to 0.70)	0.08
Diabetes	0.35 (0.004 to 0.70)	0.05	0.03
Log-IS	0.35 (0.24 to 0.47)	<0.001	0.23
Log-PCS	0.12 (0.03 to 0.21)	0.01	0.06

Multivariable analysis model R²=0.50. However, when we tested for interactions between age and group, there were no significant interactions. The estimates for group changed significantly but not for age
^aCompared to healthy controls as the reference group
^bExcludes dialysis values

ISSN: 1471-2369