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Table 1 Baseline characteristics according to the mean arterial pressure

From: Target value of mean arterial pressure in patients undergoing continuous renal replacement therapy due to acute kidney injury

Variables

Total (n = 2,211)

1st tertile (n = 746)

2nd tertile (n = 724)

3rd tertile (n = 741)

P-value

Age (year)

65.0 ± 15.2

66.4 ± 14.7

64.9 ± 15.6

63.6 ±15.1

0.001

Male (%)

60.8

58.6

60.4

63.6

0.137

Body weight (kg)

60.9 ±12.7

60.5 ± 12.5*

60.3 ± 12.8*

61.9 ± 12.8

0.034

Mechanical ventilator (%)

79.1

80.0

79.0

78.3

0.705

Vasopressors (%)

69.0

70.1

69.5

67.5

0.520

Diabetes mellitus (%)

27.1

34.8

26.7

26.7

0.802

Hypertension (%)

26.5

28.2

23.3

27.9

0.063

Ischemic heart disease (%)

11.0

11.8

10.6

10.5

0.687

COPD (%)

3.7

2.9

4.4

3.6

0.324

Cancer (%)

34.3

34.7

35.6

32.5

0.434

Mean arterial pressure (mmHg)

80.7 ± 17.3

63.3 ± 8.3

79.3 ± 3.9

99.7 ± 11.9

< 0.001

Heart rate (/min)

104.7 ± 25.9

103.4 ± 26.4

104.9 ± 24.8

105.7 ± 26.4

0.235

Respiratory rate (/min)

23.5 ± 7.8

23.4 ± 7.9

23.3 ± 7.8

23.7 ± 7.7

0.646

Body temperature (°C)

36.5 ± 1.5

36.4 ± 1.9

36.5 ± 1.3

36.5 ±1.2

0.093

FiO2

0.6 [0.4–0.9]

0.6 [0.4–1.0]

0.6 [0.4–0.9]

0.6 [0.4–0.9]

0.172

PaO2

92.0 [71.0–128.0]

89.5 [70.0–124.0]

96.5 [73.0–133.0]

90.0 [69.8–128.3]

0.311

AaDO2

253.7 [122.4–469.0]

284.6 [132.9–499.9]

241.6 [119.7–454.1]

243.3 [119.2–471.1]

0.161

Laboratory findings

 pH

7.3 ± 0.2

7.3 ± 0.1

7.3 ± 0.1

7.3 ± 0.1

0.003

 White blood cells (×103/uL)

11.9 [6.7–18.7]

11.6 [6.5–19.5]

11.9 [7.0–18.6]

12.2 [6.7–18.3]

0.609

 Hemoglobin (g/dL)

9.8 ± 2.1

9.7 ± 2.0*

9.7 ± 2.2*

10.0 ± 2.1

0.019

 Platelet (×103/uL)

102.0 [59.0–166.0]

98.0 [59.0–157.0]

103.0 [58.0–171.0]

105.0 [58.0–171.0]

0.906

 Sodium (mmol/L)

138.5 ± 7.6

138.8 ± 8.0

138.1 ± 7.5

138.5 ± 7.2

0.154

 Potassium (mmol/L)

4.4 ± 1.0

4.4 ± 1.0

4.3 ± 0.9

4.4 ± 1.0

0.313

 BUN (mg/dL)

44.0 [29.0–65.0]

41.0 [27.0–64.0]

45.5 [30.0–66.0]

45.0 [30.0–65.0]

0.243

 Creatinine (mg/dL)

2.4 [1.6–3.5]

2.2 [1.6–3.3]*

2.4 [1.6–3.6]

2.5 [1.6–3.7]

0.031

 Albumin (g/dL)

2.8 ± 0.6

2.7 ± 0.6

2.8 ± 0.6*

2.9 ± 0.6

< 0.001

 Bilirubin (mg/dL)

1.8 [0.8–4.1]

1.9 [0.9–4.1]

1.9 [0.8–4.5]

1.6 [0.8–3.7]

0.935

CRRT dose (ml/kg/hr)

40.0 [35.0–42.0]

40.0 [35.0–43.8]

40.0 [35.0–44.0]

40.0 [35.0–40.0]

0.402

APACHE II

22.4 ± 9.7

24.6 ± 9.8

21.1 ± 9.5

21.3 ± 9.5

< 0.001

  1. All continuous variables were represented with median [interquartile range]
  2. COPD Chronic obstructive pulmonary disease, MAP mean arterial pressure, AaDO2 alveolar-arterial oxygen difference, BUN blood urea nitrogen, CRRT continuous renal replacement therapy, APACHE Acute Physiology and Chronic Health Evaluation
  3. *P < 0.05; P < 0.01; P < 0.001, compared with the 3rd tertile