Table 3 Metrics for improvement in risk prediction of outcomes with addition of (continuous) sST2

Adjusted HR per twofold increase sST2 (95% CI)

1.36 (1.05, 1.76)

1.65 (1.09, 2.48)

1.30 (0.97, 1.73)

 Original model

0.767

0.809

0.773

 Original model + sST2

0.770

0.809

0.772

Difference

0.003

0.000

−0.001

P value

0.510

0.993

0.870

IDI^a (95% CI)

0.004 (−0.005–0.026)

0.020 (− 0.002–0.062)

0.007 (− 0.003–0.029)

P value

0.472

0.096

0.269

NRI(> 0)^a (95% CI)

0.172 (− 0.248–0.398)

0.186 (− 0.292–0.518)

−0.014 (− 0.348–0.320)

P value

0.365

0.429

1.000

Adjusted HR per twofold increase sST2 (95% CI)

1.33 (1.06–1.67)

1.50 (1.03–2.18)

1.40 (1.08–1.80)

 Original model

0.757

0.792

0.756

 Original model + sST2

0.761

0.791

0.756

Difference

0.004

−0.001

0.000

P value

0.257

0.894

0.909

IDI ^a (95% CI)

0.005 (−0.004–0.025)

0.014 (− 0.002–0.053)

0.011 (− 0.003–0.032)

P value

0.385

0.106

0.126

NRI(> 0) ^a (95% CI)

0.212 (− 0.128–0.432)

0.122 (− 0.188–0.428)

0.186 (−0.144–0.454)

P value

0.159

0.332

0.173