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Table 3 Predictors of AKI by univariate and multivariable logistic regression analysis

From: Incidence, predictors and prognosis of acute kidney injury in nonagenarians: an in-hospital cohort study

Variables

AKI

Univariate

Multivariable

Yes (n = 196)

No (n = 240)

OR (CI 95%)

p

OR (CI 95%)

p

Male gender

n/total (%)

61/196 (31.1%)

51/240 (21.2%)

1.68 (1.09–2.60)

0.019

  

Age, years

(mean ± SD)

93.4 ± 3.1

93.7 ± 3.6

0.98 (0.93–1.04)

0.480

  

Charlson’s

score ≥ 6

n/total (%)

113/196 (57.6%)

112/240 (46.7%)

1.56 (1.06–2.28)

0.023

  

Length of hospital stay, days (mean ± SD)

21 ± 19.4

13 ± 12.1

1.04 (1.02–1.06)

< 0.001

1.03 (1.01–1.05)

0.003

ICU admission

n/total (%)

173/196 (88.3%)

159/240 (66.2%)

3.83 (2.30–6.39)

< 0.001

1.83 (1.01–3.35)

0.048

Mechanical ventilation n/total (%)

76/196 (38.8%)

20/240 (8.3%)

6.97 (4.06–11.97)

< 0.001

2.46 (1.16–5.23)

0.019

Vasopressors

n/total (%)

103/195 (52.8%)

34/240 (14.2%)

6.78 (4.29–10.73)

< 0.001

2.43 (1.29–4.58)

0.006

Nephrotoxic antibiotics

n/total (%)

13/158 (8.2%)

8/191 (4.2%)

2.05 (0.83–5.08)

0.121

  

ACE-i or ARB

n/total (%)

62/158 (39.2%)

72/191 (37.7%)

1.04 (0.67–1.60)

0.861

  

Diuretics

n/total (%)

115/158 (72.8%)

98/191 (51.3%)

2.54 (1.62–3.98)

< 0.001

  

Corticosteroids

n/total (%)

63/158 (39.9%)

33/191 (17.3%)

3.17 (1.94–5.19)

< 0.001

  

Iodinated contrast

11/195 (5.6%)

15/240 (6.2%)

0.90 (0.80–0.90)

0.790

  
  1. Legend: AKI Acute kidney injury, OR Odds ratio, CI Confidence interval, SD Standard deviation, ICU Intensive care unit, ACE-i Inhibitor of angiotensin-converting-enzyme, ARB Angiotensin II receptors blockers. The following variables entered the multivariable logistic regression model: male gender, Charlson’s score ≥ 6, length of hospital stay, ICU admission, mechanical ventilation, vasopresssors, diuretics and corticosteroids. The last column only shows the ones that remained statistically significant at the last step of the multivariable model
  2. Bold entries are variables with p values < 0.10 on univariate analyses were selected for inclusion in stepwise backward multivariable logistic regression models and variables with p values < 0.05 in final analyses were considered statistically significant