Table 1 Patient demographic characteristics
Characteristic | Overall | Control group | Treatment group | p value |
|---|---|---|---|---|
Number of patients | 1374 | 1047 | 327 | Â |
Age (years) | 68 (57–76) | 67 (55–76) | 71 (61–78) | < 0.001 |
Male sex | 919 (66.9) | 702 (67.0) | 217 (66.4) | 0.818 |
Height (cm) | 164 (156–169) | 164 (156–169) | 164 (156–169) | 0.59 |
Body weight (kg) | 59 (50–68) | 59 (50–68) | 58 (50–68) | 0.762 |
ICU admission route | Â | Â | Â | 0.055 |
 OR (elective) | 404 (29.4) | 291 (27.8) | 113 (34.6) |  |
 OR (emergency) | 223 (16.2) | 177 (16.9) | 46 (14.1) |  |
 Emergency department | 336 (24.5) | 270 (25.8) | 66 (20.2) |  |
 Ward | 375 (27.3) | 284 (27.1) | 91 (27.8) |  |
 Other hospital | 36 (2.6) | 25 (2.4) | 11 (3.4) |  |
Comorbidity | ||||
 Hematologic disease | 51 (3.7) | 27 (2.6) | 24 (7.3) | < 0.001 |
 Metastatic cancer | 49 (3.6) | 39 (3.7) | 10 (3.1) | 0.57 |
 Immunosuppression | 123 (9.0) | 86 (8.2) | 37 (11.3) | 0.086 |
 Liver failure | 39 (2.8) | 26 (2.5) | 13 (4.0) | 0.156 |
Primary damaged organ | Â | Â | Â | 0.117 |
 Cardiovascular | 550 (40.0) | 423 (40.4) | 127 (38.8) |  |
 Respiratory | 237 (17.2) | 181 (17.3) | 56 (17.1) |  |
 Digestive | 239 (17.4) | 187 (17.9) | 52 (15.9) |  |
 Neurologic | 212 (15.4) | 147 (14.0) | 65 (19.9) |  |
 Other | 136 (9.9) | 109 (10.4) | 27 (8.3) |  |
Infection at ICU admission | 254 (18.5) | 201 (19.2) | 53 (16.2) | 0.224 |
NPPV | 147 (10.7) | 108 (10.3) | 39 (11.9) | 0.411 |
MV duration (h) (n = 837) | 17.5 (10.0–68.8) | 17.5 (10.3–64.9) | 16.6 (8.9–87.7) | 0.821 |
APACHE II score | 18 (14–22) | 18 (14–22) | 18 (14–23) | 0.384 |
Serum creatinine (μmol/L) | ||||
 Baseline | 73 (63–86) | 73 (62–82) | 76 (66–99) | < 0.001 |
 ICU admission | 87 (65–134) | 81 (61–122) | 107 (81–152) | < 0.001 |
 AKI diagnosis | 90 (65–141) | 83 (60–126) | 123 (88–171) | < 0.001 |
ICU-AKI (h) | 12.7 (7.4–25.0) | 13.9 (7.7–27.6) | 10.1 (6.7–15.6) | < 0.001 |