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Table 3 Predicators for VA-AKI in Hong Kong

From: Vancomycin-associated acute kidney injury in Hong Kong in 2012–2016

 

OR

Model 1

Model 2

Model 3

Model 4

Male

0.96 (0.86, 1.08)

Age

 Newborn and infants

Reference

 Children 1 to 12 years of age

2.93 (1.63, 5.27)*

 Adults and adolescents above 12 years of age

2.09 (1.39, 3.13)*

 Elderly patients

1.91 (1.29, 2.84)

Chemistry profile

 Baseline creatinine

1.00 (1.00, 1.00)*

1.00 (1.00, 1.00)*

1.00 (1.00, 1.00)*

1.00 (1.00, 1.00)*

 Trough vancomycin level

1.04 (1.04, 1.05)*

1.05 (1.04, 1.05)*

1.04(1.04, 1.05)*

1.04 (1.04,1.05)*

1.04 (1.04,1.05)*

Classification of vancomycin level (mg/L)

  < 10.0

Reference

Reference

Reference

Reference

Reference

 10.0~15.0

1.55 (1.34, 1.81)*

1.68 (1.44, 1.96)*

1.63 (1.39, 1.92)*

1.62 (1.38,1.89)*

1.64 (1.40,1.93)*

 15.1~20.0

2.50 (2.13, 2.93)*

2.75 (2.33, 3.24)*

2.62 (2.21, 3.11)*

2.61 (2.20,3.08)*

2.62 (2.21,3.11)*

  > 20.0

3.89 (3.34, 4.53)*

4.29 (3.67, 5.02)*

3.93 (3.34, 4.63)*

4.05 (3.45,4.77)*

4.07 (3.46,4.79)*

Comorbidities

 Pneumonia

1.06 (0.94, 1.19)

1.07 (0.96, 1.21)

 Essential hypertension

1.23 (1.10, 1.38)*

1.33 (1.18, 1.50)*

 

 Urinary tract infection

0.87 (0.77, 0.98)#

0.88 (0.77, 1.00)

 Fever

0.97 (0.86, 1.09)

0.98 (0.87, 1.11)

 Anemia

1.29 (1.14, 1.45)*

1.30 (1.15, 1.48)*

 Respiratory failure

1.39 (1.22, 1.58)*

1.39 (1.22, 1.58)*

 Type II DM

1.25 (1.10, 1.41)*

1.28 (1.13, 1.46)*

 Sepsis

1.03 (0.90, 1.19)

1.05 (0.91, 1.20)

 

 Chronic renal failure

3.17 (2.72, 3.70)*

3.18 (2.72, 3.71)*

 Congestive heart failure

1.56 (1.37, 1.79)*

1.63 (1.42, 1.87)*

Concomitant drugs

 Inotropic agents

1.26 (1.05, 1.50)#

1.28 (1.07, 1.53)#

1.19 (0.99,1.43)

 Diuretics

1.71 (1.51, 1.94)*

1.72 (1.51, 1.95)*

1.49 (1.31,1.70)*

 

 ACEI

1.25 (1.11, 1.41)*

1.27 (1.12, 1.43)*

1.11 (0.98,1.27)

 ARB

1.46 (1.20, 1.77)*

1.47 (1.21, 1.79)*

1.15 (0.94,1.42)

 PTZ

1.39 (1.24, 1.57)*

1.41 (1.25, 1.59)*

1.39 (1.23,1.57)*

 Meropenem

1.29 (1.16, 1.45)*

1.29 (1.15, 1.44)*

1.23 (1.10,1.39)*

 Aminoglycoside

1.71 (0.96, 1.22)

1.07 (0.95, 1.21)#

1.05 (0.94,1.18)

 Cefepime

1.31 (1.01, 1.71)

1.29 (0.99, 1.69)

1.04 (0.92,1.18)

 

 Amphotericin B

0.84 (0.73, 0.98)#

0.84 (0.72, 0.97)

1.24 (0.95,1.63)

 NSAIDs

1.00 (1.00, 1.00)#

1.00 (1.00, 1.00)

0.93 (0.80,1.09)

Length of Stay

0.97 (0.86, 1.09)

0.98 (0.87, 1.11)

1.00 (1.00,1.00)

1.00 (1.00,1.00)#

  1. Data is expressed as odds ratio (95% confidence interval)
  2. -Not available or not in the equation
  3. Model 1: adjusted for age and gender
  4. Model 2: additionally, adjusted for comorbidities;
  5. Model 3: additionally, adjusted for medications;
  6. Model 4: additionally, adjusted for baseline creatinine and length of stay
  7. *p < 0.001 #p < 0.05