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Table 3 Comparison of clinical characteristics among the patients using different dose of flurbiprofen axetil

From: Low dose of flurbiprofen axetil decrease the rate of acute kidney injury after operation: a retrospective clinical data analysis of 9915 cases

Factors

Non Use group (n = 7469)

Low dose group (n = 1920)

Middle dose group

(n = 462)

Large dose group

(n = 64)

P

Fundamental state

 Male, n (%)

3355 (44.9)

966 (50.3)

217 (47.0)

32 (50.0)

< 0.001

 Age (Year)

53.6 ± 14.7

50.8 ± 13.4

50.8 ± 13.8

49.5 ± 15.7

< 0.001

 Preoperative hemoglobin (g/dl)

8.9 ± 5.2

9.2 ± 5.3

9.0 ± 5.3

9.7 ± 5.6

0.16

 Hypertension, n (%)

1728 (23.1)

319 (16.6)

75 (16.2)

9 (14.1)

< 0.001

 Preoperative serum creatinine, (μmol/L)

91.7 ± 122.4

75.2 ± 74.8

74.2 ± 80.7

70.8 ± 43.1

< 0.001

 Diabetes, n (%)

510 (6.8)

102 (5.3)

35 (7.6)

3 (4.7)

0.071

 preoperative chronic kidney disease, n (%)

586 (7.8)

87 (4.5)

15 (3.2)

2 (3.1)

< 0.001

 ASA Grade, n (%)

    

0.001

  I

511 (6.8)

155 (8.1)

44 (9.5)

6 (9.4)

 

  II

4733 (63.4)

1285 (66.9)

288 (62.3)

43 (67.2)

 

  III

2225 (29.8)

480 (25.0)

130 (28.1)

15 (23.4)

 

Preoperative medication

 ACE inhibitors, n (%)

407 (5.4)

62 (3.2)

13 (2.8)

3 (4.7)

< 0.001

 ARB, n (%)

262 (3.5)

39 (2.0)

13 (2.8)

0 (0.0)

0.003

 CCB, n (%)

2095 (28.0)

348 (18.1)

84 (18.2)

6 (9.4)

< 0.001

 Diuretics, n (%)

160 (2.1)

17 (0.9)

4 (0.9)

0 (0.0)

< 0.001

Surgery-related factors

 In fluids amount

1041.7

1041.7

1333.3

1292.1

0.029

  (10 ml/24 h)

(625.0–1520.8)

(666.7–1500.0)

(875.0–1750.0)

(875.0–1692.7)

 Out fluids amount

333.3

333.3

416.7

371.9

0.028

  (10 ml/24 h)

(125.0–600.0)

(166.7–583.3)

(229.2–708.3)

(208.3–614.6)

 Emergency, n (%)

1065 (14.3)

169 (8.8)

41 (8.9)

5 (7.8)

< 0.001

 General anesthesia, n (%)

6175 (82.7)

1623 (84.5)

408 (88.3)

53 (82.8)

0.006

 Surgery grade, n (%)

    

< 0.001

  0

425 (5.7)

72 (3.8)

6 (1.3)

1 (1.6)

 

  1

2581 (34.6)

744 (38.8)

126 (27.3)

17 (26.6)

 

  2

4211 (56.4)

1061 (55.3)

320 (69.3)

44 (68.8)

 

  3

252 (3.4)

43 (2.2)

10 (2.2)

2 (3.1)

 

 Surgery time, n (%)

    

< 0.001

  <2 h

2845 (38.1)

595 (31.0)

79 (17.1)

16 (25.0)

 

  2 h–5 h

3870 (51.8)

1125 (58.6)

321 (69.5)

39 (60.9)

 

  >5 h

754 (10.1)

200 (10.4)

62 (13.4)

9 (14.1)

 

 Intraoperative erythrocyte transfusion, ml (%)

    

< 0.001

  < 100

5409 (72.4)

1491 (77.7)

307 (66.5)

44 (68.8)

 

  100–600

782 (10.5)

183 (9.5)

56 (12.1)

10 (15.6)

 

  601–1000

603 (8.1)

123 (6.4)

45 (9.7)

6 (9.4)

 

  > 1000

675 (9.0)

124 (6.5)

54 (11.7)

4 (6.3)

 

 Intraoperative haemorrhage,ml (%)

    

< 0.001

  < 100

2269 (30.4)

487 (25.4)

41 (8.9)

5 (7.8)

 

  100–600

3796 (50.8)

1056 (55.0)

307 (66.5)

42 (65.6)

 

  601–1000

635 (8.5)

187 (9.7)

41 (8.9)

6 (9.4)

 

  > 1000

769 (10.3)

190 (9.9)

73 (15.8)

11 (17.2)

 
  1. Note: AKI acute kidney injury, Scr serum creatinine, ASA American Society of Anesthesiologists