Factors | Non Use group (n = 7469) | Low dose group (n = 1920) | Middle dose group (n = 462) | Large dose group (n = 64) | P |
---|---|---|---|---|---|
Fundamental state | |||||
Male, n (%) | 3355 (44.9) | 966 (50.3) | 217 (47.0) | 32 (50.0) | < 0.001 |
Age (Year) | 53.6 ± 14.7 | 50.8 ± 13.4 | 50.8 ± 13.8 | 49.5 ± 15.7 | < 0.001 |
Preoperative hemoglobin (g/dl) | 8.9 ± 5.2 | 9.2 ± 5.3 | 9.0 ± 5.3 | 9.7 ± 5.6 | 0.16 |
Hypertension, n (%) | 1728 (23.1) | 319 (16.6) | 75 (16.2) | 9 (14.1) | < 0.001 |
Preoperative serum creatinine, (μmol/L) | 91.7 ± 122.4 | 75.2 ± 74.8 | 74.2 ± 80.7 | 70.8 ± 43.1 | < 0.001 |
Diabetes, n (%) | 510 (6.8) | 102 (5.3) | 35 (7.6) | 3 (4.7) | 0.071 |
preoperative chronic kidney disease, n (%) | 586 (7.8) | 87 (4.5) | 15 (3.2) | 2 (3.1) | < 0.001 |
ASA Grade, n (%) | 0.001 | ||||
I | 511 (6.8) | 155 (8.1) | 44 (9.5) | 6 (9.4) | |
II | 4733 (63.4) | 1285 (66.9) | 288 (62.3) | 43 (67.2) | |
III | 2225 (29.8) | 480 (25.0) | 130 (28.1) | 15 (23.4) | |
Preoperative medication | |||||
ACE inhibitors, n (%) | 407 (5.4) | 62 (3.2) | 13 (2.8) | 3 (4.7) | < 0.001 |
ARB, n (%) | 262 (3.5) | 39 (2.0) | 13 (2.8) | 0 (0.0) | 0.003 |
CCB, n (%) | 2095 (28.0) | 348 (18.1) | 84 (18.2) | 6 (9.4) | < 0.001 |
Diuretics, n (%) | 160 (2.1) | 17 (0.9) | 4 (0.9) | 0 (0.0) | < 0.001 |
Surgery-related factors | |||||
In fluids amount | 1041.7 | 1041.7 | 1333.3 | 1292.1 | 0.029 |
(10 ml/24 h) | (625.0–1520.8) | (666.7–1500.0) | (875.0–1750.0) | (875.0–1692.7) | |
Out fluids amount | 333.3 | 333.3 | 416.7 | 371.9 | 0.028 |
(10 ml/24 h) | (125.0–600.0) | (166.7–583.3) | (229.2–708.3) | (208.3–614.6) | |
Emergency, n (%) | 1065 (14.3) | 169 (8.8) | 41 (8.9) | 5 (7.8) | < 0.001 |
General anesthesia, n (%) | 6175 (82.7) | 1623 (84.5) | 408 (88.3) | 53 (82.8) | 0.006 |
Surgery grade, n (%) | < 0.001 | ||||
0 | 425 (5.7) | 72 (3.8) | 6 (1.3) | 1 (1.6) | |
1 | 2581 (34.6) | 744 (38.8) | 126 (27.3) | 17 (26.6) | |
2 | 4211 (56.4) | 1061 (55.3) | 320 (69.3) | 44 (68.8) | |
3 | 252 (3.4) | 43 (2.2) | 10 (2.2) | 2 (3.1) | |
Surgery time, n (%) | < 0.001 | ||||
<2 h | 2845 (38.1) | 595 (31.0) | 79 (17.1) | 16 (25.0) | |
2 h–5 h | 3870 (51.8) | 1125 (58.6) | 321 (69.5) | 39 (60.9) | |
>5 h | 754 (10.1) | 200 (10.4) | 62 (13.4) | 9 (14.1) | |
Intraoperative erythrocyte transfusion, ml (%) | < 0.001 | ||||
< 100 | 5409 (72.4) | 1491 (77.7) | 307 (66.5) | 44 (68.8) | |
100–600 | 782 (10.5) | 183 (9.5) | 56 (12.1) | 10 (15.6) | |
601–1000 | 603 (8.1) | 123 (6.4) | 45 (9.7) | 6 (9.4) | |
> 1000 | 675 (9.0) | 124 (6.5) | 54 (11.7) | 4 (6.3) | |
Intraoperative haemorrhage,ml (%) | < 0.001 | ||||
< 100 | 2269 (30.4) | 487 (25.4) | 41 (8.9) | 5 (7.8) | |
100–600 | 3796 (50.8) | 1056 (55.0) | 307 (66.5) | 42 (65.6) | |
601–1000 | 635 (8.5) | 187 (9.7) | 41 (8.9) | 6 (9.4) | |
> 1000 | 769 (10.3) | 190 (9.9) | 73 (15.8) | 11 (17.2) |