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Table 4 Comparison of odds ratios of AKI across different dose group of flurbiprofen axetil by multivariate regression analysis

From: Low dose of flurbiprofen axetil decrease the rate of acute kidney injury after operation: a retrospective clinical data analysis of 9915 cases

Groups

 

Model 1 P

Model 2 P

Model 3 P

Non-use

1

1

1

Low dose group (50-100 mg)

0.61 (0.48, 0.77) < 0.0001

0.71 (0.56, 0.90) 0.0042

0.75 (0.59, 0.95) 0.0188

Middle dose group (150-200 mg)

0.80 (0.54, 1.19)0.2689

0.92 (0.61, 1.39) 0.6847

0.99 (0.65, 1.49) 0.9489

Large dose group (≥250 mg)

2.98 (1.58, 5.62) 0.0007

4.15 (2.18, 7.90) < 0.0001

4.80 (2.49, 9.26) < 0.0001

  1. Model 1:Non-adjusted
  2. Model 2:adjusted for age, sex, preoperative hemoglobin, hypertension, diabetes, use of ACE inhibitors, CCB and diuretics, general anesthesia, emergency, ASA grade, surgery grade, in fluids amount, out fluids amount. Hosmer-Lemeshougoodness test: P = 0.295
  3. Model 3: adjusted for age, sex, preoperative hemoglobin, hypertension, diabetes, use of ACE inhibitors, ARB, CCB and diuretics, general anesthesia, emergency, ASA grade, surgery grade, in fluids amount, out fluids amount, surgery time, intraoperative erythrocyte transfusion, intraoperative haemorrhage and preoperative chronic kidney disease. Hosmer-Lemeshou goodness test: P = 0.123
  4. Note: AKI acute kidney injury, ASA American Society of Anesthesiologists
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BMC Nephrology

ISSN: 1471-2369

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