Low dose of flurbiprofen axetil decrease the rate of acute kidney injury after operation: a retrospective clinical data analysis of 9915 cases

Table 5 Compare of Odds Ratios of Acute Kidney Injury across different dose group of flurbiprofen axetil by ordinal logistic regression analysis

Groups	Model 1	Model 2	Model 3
Groups	P	P	P
Non-use	0	0	0
Low dose group (50-100 mg)	− 0.0396 (− 0.0587,-0.0204) < 0.0001	−0.0117 (− 0.0215,-0.0019) 0.0198	−0.0194 (− 0.0385,-0.0003) 0.0463
Middle dose group (150-200 mg)	− 0.0262 (− 0.0621,-0.0096) 0.1513	−0.0025 (− 0.0208,-0.0158) 0.7908	−0.0064 (− 0.0419,0.0292) 0.7260
Large dose group (≥250 mg)	0.1458 (0.0520,0.2397) 0.0023	0.0991 (0.0504,0.1477) < 0.0001	0.1834 (0.0910,0.2758) 0.0001

Model 1: Non-adjusted
Model 2: adjusted for age, sex, preoperative hemoglobin, hypertension, diabetes, use of ACE inhibitors, CCB and diuretics, general anesthesia, emergency, ASA grade, surgery grade, in fluids amount, out fluids amount
Hosmer-Lemeshou goodness test: P = 0.279
Model 3: adjusted for age, sex, preoperative hemoglobin, hypertension, diabetes, use of ACE inhibitors, ARB, CCB and diuretics, general anesthesia, emergency, ASA grade, surgery grade, in fluids amount, out fluids amount, surgery time, intraoperative erythrocyte transfusion, intraoperative haemorrhage and preoperative chronic kidney disease
Hosmer-Lemeshou goodness test: P = 0.121
Note: AKI: acute kidney injury; We divided the patients into three groups according to the stages of AKI:stage 0 = no AKI, stage1 = AKI grade 1, stage2 = AKI grade2 and 3
ASA American Society of Anesthesiologists

ISSN: 1471-2369