Domain | Measure | Type | Explanation | Scale / cut-off |
---|---|---|---|---|
Functional status | Activities of Daily Living (Katz) [14] | SAQ | Grading of dependency on 6 functions, e.g. bathing, dressing. | 0ā12, higher scores indicating more dependency, no cut-off values. |
Ā | Instrumental Activities of Daily Living (Lawton) [15] | SAQ | Grading of dependency on 8 more complex functions, e.g. handling finances, driving. | 0ā8 for women, 0ā5 for men. Higher scores indicating more independency, no cut-off values. |
Ā | Fall risk assessment | IAQ | One-year history of falling and graded fear of falling. | Yes/no; 1 (āno fearā) to 10 (āvery afraidā). |
Ā | Hand grip strength | T | Measured using a Jamar handheld dynamometer, 3 repetitive measurements for both hands. | Highest measurement is used for analysis. Individual cut-off values based on age and gender [16]. |
Psychological status | Montreal Cognitive Assessment (MoCA) [17] | T | Screening tool for cognitive impairment in 8 domains (visuospatial, naming, memory, attention, language, abstraction, delayed recall, orientation). | 0ā30, higher scores indicating better cognitive performance, <ā26 indication of cognitive impairment. |
Ā | Six-item Cognitive Impairment Test (6-CIT) [18] | T | Fast, 6-item screening tool for dementia, assessing orientation, attention and memory. | 0ā28, higher scores indicating worse cognitive performance, >ā10 indication of cognitive impairment. |
Ā | Letter-Digit Substitution Test (LDST) [19] | T | Speed-dependent task to measure speed of processing by matching letters to corresponding numbers provided in the key. | 0ā135 correct matches after 60ās, reference values based on age, gender and level of education [20]. |
Ā | Geriatric Depression Scale (GDS-15) [21] | IAQ | Initial two-item screening tool (āWhooley-questionsā) on mood and anhedonia, if any of the 2 positive followed by 15 additional binary questions [22]. | Yes/no, 0ā15, higher scores indicating more or stronger degree of depressive symptoms, >ā5 indicative of depression. |
Ā | Life Orientation Test - Revised (LOT-R) [23] | SAQ | 10 Items including 4 filler items, 3 items for optimism and 3 items for pessimism. Scored using 5-point Likert scales. | 0ā12 per construct (optimism or pessimism) or 0ā24 for total score (higher scores then indicating more optimism). Reference values based on age and gender [24]. |
Somatic status | Clinical Frailty Scale [25] | CA | Clinicians judgement of frailty based on 9 pictures with accompanying text. | 1 (āvery fitā) to 9 (āterminally illā). |
Ā | Charlson Comorbidity Index [26] | CA | Comorbid conditions with weighted scores for the condition. | 1ā6 per condition, total range of 0ā33. Higher scores indicating more or more severe comorbidity. No cut-off values. |
Ā | Surprise question | CA | Clinicians response to the question: āWould I be surprised if the patient died in the next 12āmonths?ā, assessed by either nephrologist or (predialysis) nurse | Yes/no. |
Ā | Mini Nutritional Assessment - Short Form (MNA-SF) [27] | IAQ | 6 Questions for assessing the risk of malnourishment. | 0ā7 āmalnourishedā, 8ā11 ārisk of malnourishmentā, 12ā14 āwell-nourishedā. |
HRQoL and symptoms | Twelve-item Short Form Health Survey (SF-12) [28] | SAQ | 12 Questions regarding HRQoL, resulting in a mental and physical component score. Scored using 3- and 5-point Likert scales. Used in Dutch nephrological care as PRO. | 0ā100, higher scores indicating better HRQoL, no cut-off values. |
Ā | Dialysis Symptom Index (DSI) [29] | SAQ | 30 Questions regarding presence of specific symptoms, when present scored on a 5-point Likert scale. Used in Dutch nephrological care as PRO. | Yes/no, if yes 1 (ānot at allā) to 5 (āvery muchā). Total score 0ā30 for each āyesā, higher scores indicating higher number of symptoms. No cut-off values. |
Costs | Five-level EQ-5D (EQ-5D-5L) [30] | SAQ | 5 Questions regarding health aspects (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) using a 5-point Likert scale and 1 overall health score on a visual-analogue scale. Used to calculate QALYs in cost-effectiveness analysis | 1 (āno problemsā) to 5 (āunable to/extreme problemsā); 0 āworst health you can imagineā to 100 (āthe best health you can imagineā for the visual-analogue scale. Reference values using Dutch value set [31]. |
Ā | (subset of questions from) iMTA Productivity & Medical Costs Questionnaire [32, 33] | SAQ | 8 General questions and 22 questions on healthcare use in the previous 3āmonths. Used to calculate healthcare-related costs in cost-effectiveness analysis. | NA |
Decisional regret | Treatment Choice Questionnaire & Decisional Conflict Scale (DCS) [34, 35] | SAQ | Questionnaire filled in when treatment choice has been made. Contains 23 questions regarding the choice made. | NA for Treatment Choice Questionnaire; 0ā100 for DCS, higher scores indicating higher decisional conflict, no cut-off values. |
Ā | Decision Regret Scale (DRS) [36] | SAQ | 5 Questions on regret regarding the choice for either conservative care or dialysis on a 5-point Likert scale. | 0ā25, higher scores indicating stronger feelings of regret. No cut-off or reference values [37]. |