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Table 5 Comparison of light microscopic findings according to the location of immunofluorescence deposits at diagnosis

From: Immunofluorescence deposits in the mesangial area and glomerular capillary loops did not affect the prognosis of immunoglobulin a nephropathy except C1q:a single-center retrospective study

Parameters

N

Segmental

glomerulosclerosis (%)

Global

glomerulosclerosis (%)

Crescent

(cellular or fibrocellular) (%)

IgA

Mesangial-only

251

9.1 (0.0,18.2)

12.5 (3.2,27.3)

0.0 (0.0,6.4)

 

Mesangial +GCLs

86

11.9 (4.0,20.3)

13.3 (5.5,30.8)

0.0 (0.0,9.5)

 

P

 

0.094

0.469

0.107

IgG

(−)

258

10.0 (0.0,18.8)

14.3 (0.0,30.0)

0.0 (0.0,7.7)

 

Mesangial-only

32

7.5 (0.0,14.1)

9.7 (0.0,29.3)

0.0 (0.0,6.1)

 

Mesangial +GCLs

33

9.1 (3.9,17.9)

9.5 (4.2,20.9)

0.0 (0.0,9.8)

 

P

 

0.569

0.350

0.665

IgM

(−)

199

10.0 (0.0,18.7)

12.5 (4.0,27.6)

0.0 (0.0,8.3)

 

Mesangial-only

102

7.7 (0.0,16.2)

12.5 (0.0,27.6)

0.0 (0.0,4.0) a

 

Mesangial +GCLs

35

15.4 (6.7,21.4)

18.9 (6.2,29.4)

0.0 (0.0,7.7)

 

P

 

0.113

0.534

0.034

C3

(−)

162

9.3 (0.0,19.6)

12.5 (4.7,27.2)

0.0 (0.0,7.3)

 

Mesangial-only

127

8.3 (0.0,15.4)

12.5 (0.0,29.0)

0.0 (0.0,6.7)

 

Mesangial +GCLs

46

12.5 (6.0,20.0)

15.6 (6.6,31.4)

0.0 (0.0,9.6)

 

P

 

0.193

0.525

0.685

Fib

(−)

299

10.0 (0.0,18.2)

12.5 (4.0,28.6)

0.0 (0.0,7.7)

 

Mesangial-only

17

10.0 (5.6,26.7)

15.0 (4.0,27.5)

0.0 (0.0,7.0)

 

Mesangial +GCLs

19

9.1 (0.0,17.6)

20.0 (8.0,24.1)

0.0 (0.0,5.3)

 

P

 

0.526

0.833

0.836

C1q

(−)

303

9.5 (0.0,18.2)

12.5 (3.7,27.3)

0.0 (0.0,7.7)

 

Mesangial-only

19

15.4 (4.8,25.0)

10.0 (6.2,33.3)

0.0 (0.0,4.0)

 

Mesangial +GCLs

14

8.2 (0.0,19.5)

17.7 (11.8,50.2)

0.0 (0.0,1.9)

 

P

 

0.226

0.244

0.520

  1. Abbreviations: Fib Fibrinogen, IgG (−) without IgG deposits, IgM (−) without IgM deposits, C3(−) without C3 deposits, Fib (−) without Fib deposits, C1q (−) without C1q deposits, GCLs glomerular capillary loops
  2. * P compare between the IgA groups
  3. a P compare with (−) group
  4. b P compare with the Mesangial-only group
  5. Statistically significant at P < 0.05
  6. The patients with immune deposits in the GCLs group were excluded due to the small sample size