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Table 8 Comparison of the treatment at diagnosis and follow-up data according to the location of immunofluorescence deposits

From: Immunofluorescence deposits in the mesangial area and glomerular capillary loops did not affect the prognosis of immunoglobulin a nephropathy except C1q:a single-center retrospective study

Parameter N Corticosteroid (%) Immunosuppression (%) RAS blockade (%) Follow-up time (months) ESKD (n, %)
IgA Mesangial-only 251 21.7 37.8 65.0 64.3 (49.9,81.2) 29 (11.6)
  Mesangial +GCLs 86 15.9 43.2 54.5 61.3 (48.4,83.1) 9 (10.5)
  P   0.406 0.519 0.209 0.827 0.783
IgG (−) 258 20.6 39.7 65.2 62.5 (50.5,81.3) 33 (12.8)
  Mesangial-only 32 38.5 23.1 53.8 59.9 (39.5,68.8) 1 (3.1)
  Mesangial +GCLs 33 9.5 47.6 57.1 64.8 (51.9,93.8) 2 (6.1)
  P   0.128 0.357 0.585 0.213 0.069
IgM (−) 199 18.6 39.8 62.7 65.7 (49.7,88.1) 21 (10.6)
  Mesangial-only 102 25.9 37.9 67.2 64.4 (54.4,78.8) 12 (11.8)
  Mesangial +GCLs 35 0.0 30.0 40.0 57.5 (46.6,66.5) 4 (11.4)
  P   0.143 0.820 0.257 0.108 0.762
C3 (−) 162 20.4 43.4 70.8 73.2 (56.3,87.1) 18 (11.1)
  Mesangial-only 127 20.3 30.5 50.8 a 55.9 (48.1,74.7) a 15 (11.8)
  Mesangial +GCLs 46 14.3 35.7 50.0 58.5 (41.0,69.0) a 4 (8.7)
  P   0.861 0.252 0.021 < 0.001 0.829
Fib (−) 299 21.8 37.9 61.5 65.0 (50.4,86.0) 35 (11.7)
  Mesangial-only 17 0.0 80.0 100.0 59.4 (36.6,66.8) 3 (17.6)
  Mesangial +GCLs 19 0.0 33.3 66.7 58.4 (47.2,64.3) 0 (0.0)
  P   0.221 0.157 0.210 0.032# 0.487
C1q (−) 303 19.7 38.7 63.6 64.8 (51.1,86.0) 30 (9.9)
  Mesangial-only 19 40.0 50.0 60.0 56.8 (48.6,68.3) 5 (26.3)
  Mesangial +GCLs 14 0.0 25.0 25.0 46.2 (32.4,64.7) a 3 (21.4)
  P   0.177 0.656 0.284 0.011 0.043#
  1. Abbreviations: Fib Fibrinogen, IgG (−) without IgG deposits, IgM (−) without IgM deposits, C3(−) without C3 deposits, Fib (−) without Fib deposits, C1q (−) without C1q deposits, GCLs glomerular capillary loops, ESKD end-stage kidney disease, RAS renin-angiotensin system
  2. * P compare between the IgA groups
  3. a P compare with (−) group
  4. b P compare with the Mesangial-only group
  5. # No statistical difference in the results of post hoc comparisons using the Bonferroni method to correct significance levels
  6. Statistically significant at P < 0.05
  7. The patients with immune deposits in the GCLs-only group were excluded due to small sample size