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Table 8 Comparison of the treatment at diagnosis and follow-up data according to the location of immunofluorescence deposits

From: Immunofluorescence deposits in the mesangial area and glomerular capillary loops did not affect the prognosis of immunoglobulin a nephropathy except C1q:a single-center retrospective study

Parameter

N

Corticosteroid (%)

Immunosuppression (%)

RAS blockade (%)

Follow-up time (months)

ESKD (n, %)

IgA

Mesangial-only

251

21.7

37.8

65.0

64.3 (49.9,81.2)

29 (11.6)

 

Mesangial +GCLs

86

15.9

43.2

54.5

61.3 (48.4,83.1)

9 (10.5)

 

P

 

0.406

0.519

0.209

0.827

0.783

IgG

(−)

258

20.6

39.7

65.2

62.5 (50.5,81.3)

33 (12.8)

 

Mesangial-only

32

38.5

23.1

53.8

59.9 (39.5,68.8)

1 (3.1)

 

Mesangial +GCLs

33

9.5

47.6

57.1

64.8 (51.9,93.8)

2 (6.1)

 

P

 

0.128

0.357

0.585

0.213

0.069

IgM

(−)

199

18.6

39.8

62.7

65.7 (49.7,88.1)

21 (10.6)

 

Mesangial-only

102

25.9

37.9

67.2

64.4 (54.4,78.8)

12 (11.8)

 

Mesangial +GCLs

35

0.0

30.0

40.0

57.5 (46.6,66.5)

4 (11.4)

 

P

 

0.143

0.820

0.257

0.108

0.762

C3

(−)

162

20.4

43.4

70.8

73.2 (56.3,87.1)

18 (11.1)

 

Mesangial-only

127

20.3

30.5

50.8 a

55.9 (48.1,74.7) a

15 (11.8)

 

Mesangial +GCLs

46

14.3

35.7

50.0

58.5 (41.0,69.0) a

4 (8.7)

 

P

 

0.861

0.252

0.021

< 0.001

0.829

Fib

(−)

299

21.8

37.9

61.5

65.0 (50.4,86.0)

35 (11.7)

 

Mesangial-only

17

0.0

80.0

100.0

59.4 (36.6,66.8)

3 (17.6)

 

Mesangial +GCLs

19

0.0

33.3

66.7

58.4 (47.2,64.3)

0 (0.0)

 

P

 

0.221

0.157

0.210

0.032#

0.487

C1q

(−)

303

19.7

38.7

63.6

64.8 (51.1,86.0)

30 (9.9)

 

Mesangial-only

19

40.0

50.0

60.0

56.8 (48.6,68.3)

5 (26.3)

 

Mesangial +GCLs

14

0.0

25.0

25.0

46.2 (32.4,64.7) a

3 (21.4)

 

P

 

0.177

0.656

0.284

0.011

0.043#

  1. Abbreviations: Fib Fibrinogen, IgG (−) without IgG deposits, IgM (−) without IgM deposits, C3(−) without C3 deposits, Fib (−) without Fib deposits, C1q (−) without C1q deposits, GCLs glomerular capillary loops, ESKD end-stage kidney disease, RAS renin-angiotensin system
  2. * P compare between the IgA groups
  3. a P compare with (−) group
  4. b P compare with the Mesangial-only group
  5. # No statistical difference in the results of post hoc comparisons using the Bonferroni method to correct significance levels
  6. Statistically significant at P < 0.05
  7. The patients with immune deposits in the GCLs-only group were excluded due to small sample size