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Table 9 Univariate and multivariate analysis of ESKD or ≥ 50% decline in the eGFR

From: Immunofluorescence deposits in the mesangial area and glomerular capillary loops did not affect the prognosis of immunoglobulin a nephropathy except C1q:a single-center retrospective study

Parameters Univariate analysis P Multivariate analysis P
HR (95% CI) HR (95% CI)
Gender (Female vs Male) 1.476 (0.781, 2.790) 0.231   
Age (years) 1.000 (0.972,1.029) 0.991   
Weight (kg) 1.010 (0.982,1.038) 0.502   
SBP (mmHg) 1.030 (1.015,1.045) < 0.001 1.026 (1.001, 1.052) 0.041
DBP (mmHg) 1.030 (1.005,1.054) 0.016 0.974 (0.940, 1.009) 0.137
Hemoglobin (g/L) 0.979 (0.964,0.994) 0.006 0.990 (0.969,1.012) 0.368
Serum albumin (g/L) 0.970 (0.935,1.005) 0.089   
eGFR (ml/min/1.73m2) 0.954 (0.941, 0.967) < 0.001 0.959 (0.944, 0.974) < 0.001
Serum creatinine (μmol/L) 1.021 (1.017,1.025) < 0.001   
Triglyceride (mmol/L) 1.148 (1.064,1.240) < 0.001 1.181 (1.025,1.362) 0.022
Cholesterol (mmol/L) 1.029 (0.906,1.168) 0.665   
Serum IgA (g/L) 0.974 (0.716,1.326) 0.869   
Serum IgG (g/L) 0.916 (0.836,1.004) 0.062   
Serum IgM (g/L) 1.389 (0.956,2.018) 0.085   
Serum C3 (g/L) 2.803 (1.146,6.857) 0.024 1.426 (0.373,5.366) 0.609
Proteinuria (g/24 h) 1.171 (1.073,1.279) < 0.001 1.100 (0.958, 1.263) 0.177
M (1 vs 0) 2.323 (0.318, 16.959) 0.406   
E (1 vs 0) 1.767 (0.424, 7.366) 0.434   
S (1 vs 0) 3.152 (1.226, 8.105) 0.017 1.857 (1.022, 5.127) 0.233
T (0 vs 1 + 2) 12.370 (1.695, 90.262) 0.013 6.754 (0.872, 52.286) 0.067
C (0 vs 1 + 2) 1.198 (0.623,2.302) 0.588   
C1q (−) 1 (reference)   1 (reference)  
Mesangial-only 3.095 (1.195,8.017) 0.020 1.757 (0.595, 5.185) 0.308
Mesangial +GCLs 3.249 (0.984,10.724) 0.053 3.898 (1.022, 14.872) 0.046
  1. Abbreviations: SBP systolic blood pressure, DBP diastolic blood pressure, eGFR estimated glomerular filtration rate, C1q (−) without C1q deposits, GCLs glomerular capillary loops, M mesangial hypercellularity, E endocapillary hypercellularity, S segmental glomerulosclerosis, T tubular atrophy/interstitial fibrosis, C Cellular or fibrocellular crescents, ESKD end-stage kidney disease
  2. Statistically significant at P < 0.05