Table 9 Univariate and multivariate analysis of ESKD or ≥ 50% decline in the eGFR

Gender (Female vs Male)

1.476 (0.781, 2.790)

0.231

Age (years)

1.000 (0.972,1.029)

0.991

Weight (kg)

1.010 (0.982,1.038)

0.502

SBP (mmHg)

1.030 (1.015,1.045)

< 0.001

1.026 (1.001, 1.052)

0.041

DBP (mmHg)

1.030 (1.005,1.054)

0.016

0.974 (0.940, 1.009)

0.137

Hemoglobin (g/L)

0.979 (0.964,0.994)

0.006

0.990 (0.969,1.012)

0.368

Serum albumin (g/L)

0.970 (0.935,1.005)

0.089

eGFR (ml/min/1.73m²)

0.954 (0.941, 0.967)

< 0.001

0.959 (0.944, 0.974)

< 0.001

Serum creatinine (μmol/L)

1.021 (1.017,1.025)

< 0.001

Triglyceride (mmol/L)

1.148 (1.064,1.240)

< 0.001

1.181 (1.025,1.362)

0.022

Cholesterol (mmol/L)

1.029 (0.906,1.168)

0.665

Serum IgA (g/L)

0.974 (0.716,1.326)

0.869

Serum IgG (g/L)

0.916 (0.836,1.004)

0.062

Serum IgM (g/L)

1.389 (0.956,2.018)

0.085

Serum C3 (g/L)

2.803 (1.146,6.857)

0.024

1.426 (0.373,5.366)

0.609

Proteinuria (g/24 h)

1.171 (1.073,1.279)

< 0.001

1.100 (0.958, 1.263)

0.177

M (1 vs 0)

2.323 (0.318, 16.959)

0.406

E (1 vs 0)

1.767 (0.424, 7.366)

0.434

S (1 vs 0)

3.152 (1.226, 8.105)

0.017

1.857 (1.022, 5.127)

0.233

T (0 vs 1 + 2)

12.370 (1.695, 90.262)

0.013

6.754 (0.872, 52.286)

0.067

C (0 vs 1 + 2)

1.198 (0.623,2.302)

0.588

C1q (−)

1 (reference)

1 (reference)

Mesangial-only

3.095 (1.195,8.017)

0.020

1.757 (0.595, 5.185)

0.308

Mesangial +GCLs

3.249 (0.984,10.724)

0.053

3.898 (1.022, 14.872)

0.046