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Fig. 2 | BMC Nephrology

Fig. 2

From: Tertiary lymphoid tissue in early‐stage IgG4-related tubulointerstitial nephritis incidentally detected with a tumor lesion of the ureteropelvic junction: a case report

Fig. 2

Histopathology of renal parenchyma in the concurrently removed right kidney. a Arteriosclerosis and arteriolar hyalinosis were found. About 30 % of glomeruli were globally sclerosed. Interstitial fibrosis was faint and no storiform fibrosis was noted [Periodic acid-Schiff (PAS) staining, × 20]. b, c Lymphoplasmacytic aggregates with scant fibrosis were observed focally in perivascular areas (arrow) [PAS staining, (b) × 40, (c) × 100]. d Lymphoplasmacytic infiltration was also detected in subcapsular areas. Germinal center (GC)-like structures surrounded by IgG4+ cells were located beneath the renal capsule (IgG4 immunostaining, × 100). e, f GC-like structures surrounded by IgG4-positive cells were also observed around interlobular arteries and venules [IgG4 immunostaining, (e) × 100, (f) × 200]. g, h Immunofluorescence revealed almost all GC-like structures to be aggregates of B and T cells and a CD21-positive follicular dendritic cell network, indicating mature tertiary lymphoid tissues (× 400)

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