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Table 1 Bovine plasma pharmacokinetic parameters of apixaban during in vitro CRRT as determined via noncompartmental analysesa

From: Pharmacokinetics and dialytic clearance of apixaban during in vitro continuous renal replacement therapy

 

Cmax (ng/mL)

Clast (ng/mL)

Ke (hr−1)

t1/2 (h)

Vd (L)

CLTM (L/h)

AUC0-∞

(ng · h/mL)

AUC0-last

(ng · h/mL)

AUC0–24

(ng · h/mL)

CVVH

    

HF1400

    

 2 L/h, 50/50%

106.5 ± 0.7

23.4 ± 1.6

0.9 ± 0.0

0.8 ± 0.0

2.2 ± 0.0

1.9 ± 0.1

66.8 ± 2.7

39.3 ± 0.2

943.6 ± 4.9

 2 L/h, 100/0%

113.3 ± 21.2

21.2 ± 4.5

0.9 ± 0.2

0.8 ± 0.2

2.0 ± 0.0

1.7 ± 0.4

78.2 ± 18.5

44.5 ± 5.0

1068.9 ± 120.5

 2 L/h, 0/100%

108.5 ± 3.2

24.3 ± 2.0

1.0 ± 0.2

0.7 ± 0.2

1.9 ± 0.2

1.9 ± 0.2

66.9 ± 7.2

42.1 ± 0.3

1009.8 ± 6.8

 4 L/h, 50/50%

86.5 ± 4.5

13.1 ± 1.2

1.3 ± 0.1

0.5 ± 0.0

2.6 ± 0.4

3.3 ± 0.3

38.2 ± 3.4

27.9 ± 3.1

669.4 ± 73.5

CVVHD

         

 2 L/h

117.7 ± 1.9

26.9 ± 1.8

0.9 ± 0.1

0.8 ± 0.1

1.9 ± 0.0

1.7 ± 0.2

75.7 ± 8.1

44.1 ± 2.2

1058.0 ± 52.2

 4 L/h

119.1 ± 7.4

20.5 ± 1.6

1.2 ± 0.2

0.6 ± 0.1

1.9 ± 0.2

2.2 ± 0.1

58.1 ± 3.5

40.1 ± 0.4

962.7 ± 9.7

CVVH

    

M150

    

 2 L/h, 50/50%

107.9 ± 16.2

31.0 ± 10.2

0.9 ± 0.3

0.9 ± 0.3

1.8 ± 0.4

1.6 ± 0.7

92.5 ± 37.0

49.6 ± 11.8

1191.0 ± 283.3

 2 L/h, 100/0%

90.4 ± 13.8

34.3 ± 9.9

0.7 ± 0.3

0.9 ± 0.2

1.8 ± 0.3

1.3 ± 0.6

97.1 ± 25.6

50.6 ± 10.8

1214.3 ± 259.3

 2 L/h, 0/100%

108.4 ± 13.3

40.3 ± 9.5

0.7 ± 0.3

1.0 ± 0.2

1.5 ± 0.3

1.1 ± 0.6

117.6 ± 28.6

60.8 ± 10.7

1458.6 ± 256.9

 4 L/h, 50/50%

94.9 ± 15.1

23.2 ± 9.9

1.2 ± 0.3

0.6 ± 0.2

1.7 ± 0.4

2.1 ± 0.7

62.2 ± 29.9

42.1 ± 11.8

1009.3 ± 283.1

CVVHD

 2 L/h

117.3 ± 14.2

46.2 ± 10.4

0.7 ± 0.2

1.1 ± 0.2

1.4 ± 0.4

0.9 ± 0.7

139.2 ± 32.6

69.0 ± 12.8

1656.1 ± 307.5

 4 L/h

121.4 ± 14.3

26.9 ± 9.7

1.3 ± 0.3

0.5 ± 0.2

1.3 ± 0.3

1.6 ± 0.6

77.2 ± 29.3

56.1 ± 11.2

1346.3 ± 269.0

  1. Data are presented as mean ± SD
  2. an = 2 experiments in each mode, at each flow rate, point of dilution, and filter type (24 total experiments)