| Cmax (ng/mL) | Clast (ng/mL) | Ke (hr−1) | t1/2 (h) | Vd (L) | CLTM (L/h) | AUC0-∞ (ng · h/mL) | AUC0-last (ng · h/mL) | AUC0–24 (ng · h/mL) |
---|---|---|---|---|---|---|---|---|---|
CVVH | Â | Â | Â | Â | HF1400 | Â | Â | Â | Â |
 2 L/h, 50/50% | 106.5 ± 0.7 | 23.4 ± 1.6 | 0.9 ± 0.0 | 0.8 ± 0.0 | 2.2 ± 0.0 | 1.9 ± 0.1 | 66.8 ± 2.7 | 39.3 ± 0.2 | 943.6 ± 4.9 |
 2 L/h, 100/0% | 113.3 ± 21.2 | 21.2 ± 4.5 | 0.9 ± 0.2 | 0.8 ± 0.2 | 2.0 ± 0.0 | 1.7 ± 0.4 | 78.2 ± 18.5 | 44.5 ± 5.0 | 1068.9 ± 120.5 |
 2 L/h, 0/100% | 108.5 ± 3.2 | 24.3 ± 2.0 | 1.0 ± 0.2 | 0.7 ± 0.2 | 1.9 ± 0.2 | 1.9 ± 0.2 | 66.9 ± 7.2 | 42.1 ± 0.3 | 1009.8 ± 6.8 |
 4 L/h, 50/50% | 86.5 ± 4.5 | 13.1 ± 1.2 | 1.3 ± 0.1 | 0.5 ± 0.0 | 2.6 ± 0.4 | 3.3 ± 0.3 | 38.2 ± 3.4 | 27.9 ± 3.1 | 669.4 ± 73.5 |
CVVHD | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 2 L/h | 117.7 ± 1.9 | 26.9 ± 1.8 | 0.9 ± 0.1 | 0.8 ± 0.1 | 1.9 ± 0.0 | 1.7 ± 0.2 | 75.7 ± 8.1 | 44.1 ± 2.2 | 1058.0 ± 52.2 |
 4 L/h | 119.1 ± 7.4 | 20.5 ± 1.6 | 1.2 ± 0.2 | 0.6 ± 0.1 | 1.9 ± 0.2 | 2.2 ± 0.1 | 58.1 ± 3.5 | 40.1 ± 0.4 | 962.7 ± 9.7 |
CVVH | Â | Â | Â | Â | M150 | Â | Â | Â | Â |
 2 L/h, 50/50% | 107.9 ± 16.2 | 31.0 ± 10.2 | 0.9 ± 0.3 | 0.9 ± 0.3 | 1.8 ± 0.4 | 1.6 ± 0.7 | 92.5 ± 37.0 | 49.6 ± 11.8 | 1191.0 ± 283.3 |
 2 L/h, 100/0% | 90.4 ± 13.8 | 34.3 ± 9.9 | 0.7 ± 0.3 | 0.9 ± 0.2 | 1.8 ± 0.3 | 1.3 ± 0.6 | 97.1 ± 25.6 | 50.6 ± 10.8 | 1214.3 ± 259.3 |
 2 L/h, 0/100% | 108.4 ± 13.3 | 40.3 ± 9.5 | 0.7 ± 0.3 | 1.0 ± 0.2 | 1.5 ± 0.3 | 1.1 ± 0.6 | 117.6 ± 28.6 | 60.8 ± 10.7 | 1458.6 ± 256.9 |
 4 L/h, 50/50% | 94.9 ± 15.1 | 23.2 ± 9.9 | 1.2 ± 0.3 | 0.6 ± 0.2 | 1.7 ± 0.4 | 2.1 ± 0.7 | 62.2 ± 29.9 | 42.1 ± 11.8 | 1009.3 ± 283.1 |
CVVHD | |||||||||
 2 L/h | 117.3 ± 14.2 | 46.2 ± 10.4 | 0.7 ± 0.2 | 1.1 ± 0.2 | 1.4 ± 0.4 | 0.9 ± 0.7 | 139.2 ± 32.6 | 69.0 ± 12.8 | 1656.1 ± 307.5 |
 4 L/h | 121.4 ± 14.3 | 26.9 ± 9.7 | 1.3 ± 0.3 | 0.5 ± 0.2 | 1.3 ± 0.3 | 1.6 ± 0.6 | 77.2 ± 29.3 | 56.1 ± 11.2 | 1346.3 ± 269.0 |