Table 2 Transmembrane clearance of apixaban and urea during in vitro CRRT as determined by SC or SA * flow rate^a

CVVH

 2 L/h, 50/50%

0.608 ± 0.08

1.22 ± 0.16

1.00 ± 0.03

2.00 ± 0.06

 2 L/h, 100/0%

0.531 ± 0.06

1.06 ± 0.11

0.99 ± 0.08

1.98 ± 0.15

 2 L/h, 0/100%

0.614 ± 0.03

1.23 ± 0.06

1.09 ± 0.03

2.17 ± 0.06

 4 L/h, 50/50%

0.622 ± 0.04

2.49 ± 0.17

1.12 ± 0.03

4.47 ± 0.11

CVVHD

SA

CL_TM (L/h)

SA

CL_TM (L/h)

 2 L/h

0.622 ± 0.12

1.24 ± 0.24

1.23 ± 0.08

2.46 ± 0.16

 4 L/h

0.601 ± 0.11

2.40 ± 0.43

1.38 ± 0.17

5.53 ± 0.67

CVVH

 2 L/h, 50/50%

0.612 ± 0.03

1.22 ± 0.06

1.08 ± 0.10

2.15 ± 0.19

 2 L/h, 100/0%

0.581 ± 0.07

1.16 ± 0.14

1.01 ± 0.07

2.02 ± 0.14

 2 L/h, 0/100%

0.603 ± 0.02

1.21 ± 0.04

1.08 ± 0.05

2.16 ± 0.09

 4 L/h, 50/50%

0.540 ± 0.04

2.16 ± 0.17

1.00 ± 0.07

3.98 ± 0.29

CVVHD

SA

CL_TM (L/h)

SA

CL_TM (L/h)

 2 L/h

0.619 ± 0.01

1.24 ± 0.03

1.19 ± 0.05

2.38 ± 0.10

 4 L/h

0.555 ± 0.05

2.22 ± 0.20

1.27 ± 0.17

5.09 ± 0.66