Skip to main content

Table 5 Optimal dosing recommendations of apixaban by filter type and CRRT flow rate

From: Pharmacokinetics and dialytic clearance of apixaban during in vitro continuous renal replacement therapy

 

Mean CLTM (L/h)

 

Mean CLT (L/h)

Optimal total daily dose (mg)c

CRRT

flow rate

(L/h)

HF1400 Filter

M150 Filter

Mean

CLNR

(L/h)a

HF1400

Filter

M150

Filter

Target

AUC

(ng · h/mL)b

HF1400

Filter

M150

Filter

Optimal dosing regimend

0.5

0.95

0.13

2.52

3.47

2.65

2103.8

7.31

5.58

2.5 mg BID

1

1.26

0.44

2.52

3.78

2.96

2103.8

7.95

6.23

2.5–5 mg BID

1.5

1.57

0.75

2.52

4.09

3.27

2103.8

8.60

6.87

2.5–5 mg BID

2

1.87

1.05

2.52

4.39

3.57

2103.8

9.24

7.51

5 mg BID

2.5

2.18

1.36

2.52

4.70

3.88

2103.8

9.88

8.16

5 mg BID

3

2.48

1.66

2.52

5.00

4.18

2103.8

10.53

8.80

5 mg BID

3.5

2.79

1.97

2.52

5.31

4.49

2103.8

11.17

9.44

5 mg BID

4

3.10

2.28

2.52

5.62

4.80

2103.8

11.82

10.09

5 mg BID

4.5

3.40

2.58

2.52

5.92

5.10

2103.8

12.46

10.73

5 mg BID

5

3.71

2.89

2.52

6.23

5.41

2103.8

13.10

11.38

5–7.5 mg BID

  1. aEstimated CLNR from Byon et al. CPT Pharmacometrics Syst Pharmacol 2017;6(5):340–349
  2. bTarget AUC from Frost et al. Br J Clin Pharmacol 2013;76:776–786
  3. cTo achieve comparable mean AUC values achieved in 6 patients administered apixaban 5 mg BID for 7 days, the observed AUC0–12 (1051.9 ng · h/mL) was multiplied by two to estimate AUC0–24 and solve for dose via the equation AUC = total daily dose/CLT
  4. dRounded to the nearest 2.5 mg tablet
Back to article page

BMC Nephrology

ISSN: 1471-2369

Contact us