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Table 2 Light chain crystals in tubular casts and other tissues in multiple myeloma

From: Two kinds of rare light chain cast nephropathy caused by multiple myeloma: case reports and literature review

References

Year

No of cases

LCCC

Other kidney tissues involved

Extrarenal tissue involved

Location

type

Sikl H [25]

1949

1a

Distal

ND

PTC cytoplasm

NPC in medulla of the kidney

Neumann V [26]

1949

1a

All segments

ND

Bowman’s capsule

Interstitial cells

Bone marrow, NPC in tumour area

Schubert GE [27]

1972

7a

Distal

ND

PTC cytoplasm

Interstitium

Bone marrow

Chejfec G [28]

1983

1ba

ND

λ

No

Lung

Dornan TL [29]

1985

1a

ND

λ

Bowman’s capsule

Blood vessel

Interstitial tissue of the heart

Truong LD [30]

1989

1a

Distal

κ

PTC cytoplasm

Glomerulus

NPC in interstitium

No

Pirani CL [31]

1987

14bc

Distal

κ or λ

PTC or DTC cytoplasm (5 cases)

ND

Kanno Y [32]

2001

1b

ND

λ?

Bowman’s capsule

Bone marrow

Dehmel B [33]

2003

1b

ND

λ

PTC cytoplasm

ND

Chen KJ [34]

2005

1b

ND

λ

Glomerulus, Blood vessel, Interstitium

Bone marrow

Toly-Ndour C [35]

2011

1b

ND

λ

PTC cytoplasm

Bowman’s capsule

Bone marrow

Haider M [36]

2014

1b

Distal

λ

No

ND

Luciano RL [37]

2014

1b

ND

λ

No

ND

  

1b

Distal and Proximal

κ

PTC cytoplasm

ND

Gallan AJ [38]

2016

1b

ND

λ

No

ND

Kumakura S [39]

2016

1b

Proximal

λ

No

ND

Lerner G [40]

2020

1b

Distal

κ

PTC cytoplasm

ND

Chou A [41]

2020

1b

Distal

κ

Glomerulus, Interlobular arteries

ND

Matsumura H [42]

2020

1b

Distal

λ

No

No in bone marrow

Lin Z-S [43]

2020

1b

Distal

λ

No

ND

Our case

 

1b

Distal

λ

No

No in bone marrow

  1. LCCC light chain crystal casts, ND not detailed, NPC neoplastic plasma cells, PTC proximal tubular cell, DTC distal tubular cell
  2. a Autopsy kidney tissues. b Kidney biopsy tissue
  3. cIn this paper, definite crystals were detected histologically in 14 cases and features suggestive of crystals in another 4 cases. The 4 suspected cases are not included in this table