| Unadjusted | Adjusted for Demographics | Adjusted for Demographics and Lifestyle | Adjusted for Demographics, Lifestyle, Glycemic Control and Comorbidities | ||||
---|---|---|---|---|---|---|---|---|
Hazard Ratio (95% CI) | P- Value | Hazard Ratio (95% CI) | P- Value | Hazard Ratio (95% CI) | P- Value | Hazard Ratio (95% CI) | P- Value | |
Dichotomous SDOH score group | Â | 0.19 | Â | 0.01 | Â | 0.02 | Â | 0.01 |
No adverse SDOH factors (0) | Ref | Â | Ref | Â | Ref | Â | Ref | Â |
Adverse SDOH factors (≥1) | 1.19 (0.91–1.56) |  | a1.42 (1.07–1.88) |  | a1.38 (1.05–1.80) |  | a1.41 (1.08–1.84) |  |
Gender Female (ref Male) |  |  | a0.72 (0.53–0.97) | 0.03 | 0.64 (0.47–0.88) | < 0.01 | a0.67 (0.48–0.93) | 0.02 |
Age at Screening (Increase 1 year) |  |  | a1.06 (1.04–1.07) | < 0.01 | a1.05 (1.04–1.06) | < 0.01 | a1.05 (1.03–1.06) | < 0.01 |
Race (ref non-Hispanic White) | Â | Â | Â | 0.07 | Â | 0.06 | Â | 0.08 |
non-Hispanic Black |  |  | 0.85 (0.62–1.16) |  | 0.85 (0.62–1.15) |  | 0.84 (0.61–1.16) |  |
Other |  |  | a0.69 (0.50–0.94) |  | a0.68 (0.49–0.93) |  | a0.69 (0.50–0.95) |  |
Education level (Increase 1 level) |  |  | 0.90 (0.82–1.00) | 0.04 | 0.95 (0.86–1.05) | 0.31 | 0.97 (0.88–1.07) | 0.57 |
Insurance coverage No (ref Yes) |  |  | 0.71 (0.34–1.49) | 0.36 | 0.78 (0.37–1.66) | 0.52 | 0.75 (0.35–1.62) | 0.46 |
Lifestyle Factors | ||||||||
Physical activity Moderate to Vigorous (ref none) |  |  |  |  | a0.51 (0.38–0.69) | < 0.01 | a0.52 (0.37–0.73) | < 0.01 |
Smoking status Former or Current Smoker |  |  |  |  | a1.40 (1.10–1.80) | < 0.01 | a1.37 (1.05–1.79) | 0.02 |
Drinking status Moderate or above drinker (ref none) |  |  |  |  | a0.62 (0.46–0.83) | < 0.01 | a0.59 (0.43–0.82) | < 0.01 |
Glycemic Control | ||||||||
Hemoglobin A1c (%) (Increase 1%) |  |  |  |  |  |  | a1.10 (1.01–1.19) | 0.02 |
Comorbidity | ||||||||
Hypertension (Ref No Hypertension) |  |  |  |  |  |  | 1.02 (0.73–1.44) | 0.90 |
Heart disease (Ref No Heart Disease) |  |  |  |  |  |  | a1.80 (1.37–2.37) | < 0.01 |
Stroke (Ref No Stroke) |  |  |  |  |  |  | 0.97 (0.62–1.53) | 0.91 |
Cancer (Ref No Cancer) |  |  |  |  |  |  | a1.41 (1.00–1.99) | 0.05 |