| Unadjusted | Adjusted for Demographics | Adjusted for Demographics and Lifestyle | Adjusted for Demographics, Lifestyle, Glycemic Control and Comorbidities | ||||
---|---|---|---|---|---|---|---|---|
Hazard Ratio (95% CI) | P- Value | Hazard Ratio (95% CI) | P- Value | Hazard Ratio (95% CI) | P- Value | Hazard Ratio (95% CI) | P- Value | |
Ratio of family income to poverty group | Â | 0.09 | Â | 0.03 | Â | 0.08 | Â | 0.05 |
≤130% of poverty level (ref > 130% of poverty level) | 1.29 (0.96–1.74) |  | a1.46 (1.04–2.05) |  | 1.31 (0.97–1.79) |  | 1.40 (1.00–1.97) |  |
Household food security group | Â | 0.05 | Â | 0.17 | Â | 0.06 | Â | 0.09 |
Food insecure (ref Food secure) | 0.70 (0.49–1.00) |  | 1.27 (0.90–1.80) |  | 1.42 (0.99–2.04) |  | 1.41 (0.95–2.07) |  |
Depression group |  | 0.02 |  | < 0.01 |  | < 0.01 |  | < 0.01 |
Mild to Severe depression (ref No depression 0–4) | a1.33 (1.04–1.71) |  | a1.44 (1.12–1.86) |  | a1.45 (1.12–1.86) |  | a1.41 (1.10–1.82) |  |
Gender Female (ref Male) |  |  | a0.69 (0.51–0.93) | 0.02 | a0.61 (0.45–0.84) | < 0.01 | a0.65 (0.46–0.91) | 0.01 |
Age at Screening (Increase 1 year) |  |  | a1.06 (1.05–1.07) | < 0.01 | a1.06 (1.04–1.07) | < 0.01 | a1.05 (1.04–1.06) | < 0.01 |
Race (ref non-Hispanic White) | Â | Â | Â | 0.04 | Â | 0.03 | Â | 0.04 |
non-Hispanic Black |  |  | 0.84 (0.62–1.15) |  | 0.83 (0.61–1.13) |  | 0.82 (0.60–1.12) |  |
Other |  |  | a0.66 (0.48–0.90) |  | a0.65 (0.47–0.89) |  | a0.66 (0.47–0.91) |  |
Education level (Increase 1 level) |  |  | 0.93 (0.84–1.03) | 0.15 | 0.97 (0.88–1.08) | 0.58 | 1.00 (0.90–1.10) | 0.93 |
Insurance coverage No (ref Yes) |  |  | 0.67 (0.32–1.43) | 0.30 | 0.74 (0.35–1.57) | 0.43 | 0.69 (0.31–1.52) | 0.36 |
Lifestyle Factors | ||||||||
Physical activity Moderate to Vigorous (ref none) |  |  |  |  | a0.51 (0.38–0.69) | < 0.01 | a0.52 (0.37–0.74) | < 0.01 |
Smoking status Former or Current Smoker (ref none) |  |  |  |  | a1.38 (1.09–1.76) | < 0.01 | a1.35 (1.05–1.74) | 0.02 |
Drinking status Moderate or above Drinker (ref none) |  |  |  |  | a0.61 (0.45–0.81) | < 0.01 | a0.59 (0.43–0.82) | < 0.01 |
Glycemic Control | ||||||||
Hemoglobin A1c (%) (Increase 1%) |  |  |  |  |  |  | a1.09 (1.01–1.18) | 0.03 |
Comorbidity | ||||||||
Hypertension (Ref No Hypertension) |  |  |  |  |  |  | 2.00 (0.71–1.42) | 0.99 |
Heart disease (Ref No Heart Disease) |  |  |  |  |  |  | a1.76 (1.33–2.34) | < 0.01 |
Stroke (Ref no Stroke) |  |  |  |  |  |  | 0.99 (0.64–1.53) | 0.96 |
Cancer (Ref No Cancer) |  |  |  |  |  |  | a1.44 (1.04–2.02) | 0.03 |