From: Renal transplantation outcomes in obese patients: a French cohort-based study
Whole sample (n = 4691) | Non-obese (n = 3944) | Obese (n = 747) | p-value | |||||||
---|---|---|---|---|---|---|---|---|---|---|
NA | n | % | NA | n | % | NA | n | % | ||
Male | 0 | 2977 | 63.5 | 0 | 2563 | 65.0 | 0 | 414 | 55.4 | < 0.0001 |
Recurrent causal nephropathy (*) | 1 | 1114 | 23.8 | 1 | 983 | 24.9 | 0 | 131 | 17.5 | < 0.0001 |
Causal nephropathy | 1 | 1 | 0 | < 0.0001 | ||||||
Diabetes | 569 | 12.1 | 392 | 9.9 | 177 | 23.6 | ||||
Glomerulopathy | 935 | 19.8 | 823 | 20.8 | 112 | 15.0 | ||||
Other | 2252 | 47.8 | 1963 | 49.5 | 289 | 38.6 | ||||
Tubulointerstitial nephritis | 414 | 8.8 | 352 | 8.9 | 62 | 8.3 | ||||
Vascular disease | 540 | 11.5 | 431 | 10.9 | 109 | 14.6 | ||||
Preemptive transplantation | 8 | 450 | 9.6 | 8 | 395 | 10.0 | 0 | 55 | 7.4 | 0.0231 |
Peritoneal dialysis | 8 | 454 | 9.7 | 8 | 398 | 10.1 | 0 | 55 | 7.4 | 0.0240 |
History of diabetes | 0 | 923 | 19.7 | 0 | 637 | 16.2 | 0 | 286 | 38.3 | < 0.0001 |
History of hypertension | 0 | 3949 | 84.2 | 0 | 3301 | 83.7 | 0 | 648 | 86.7 | 0.0362 |
History of vascular disease | 0 | 837 | 17.8 | 0 | 696 | 17.6 | 0 | 141 | 18.9 | 0.4214 |
History of cardiac disease | 0 | 1355 | 28.9 | 0 | 1095 | 27.8 | 0 | 260 | 34.8 | 0.0001 |
History of cardiovascular disease | 0 | 1806 | 38.5 | 0 | 1475 | 37.4 | 0 | 331 | 44.3 | 0.0004 |
History of malignancy | 0 | 476 | 10.1 | 0 | 406 | 10.3 | 0 | 70 | 9.4 | 0.4435 |
History of dyslipidemia | 0 | 1934 | 41.2 | 0 | 1516 | 38.4 | 0 | 418 | 56.0 | < 0.0001 |
History of B or C hepatitis | 0 | 250 | 5.3 | 0 | 224 | 5.7 | 0 | 26 | 3.5 | 0.0142 |
Positive CMV serology | 47 | 3028 | 65.2 | 40 | 2515 | 64.4 | 7 | 513 | 69.3 | 0.0102 |
Positive EBV serology | 62 | 4488 | 97.0 | 53 | 3765 | 96.8 | 9 | 723 | 98.0 | 0.0806 |
Positive class I anti-HLA antibodies | 378 | 1369 | 31.7 | 318 | 1145 | 31.6 | 60 | 224 | 32.6 | 0.5956 |
Positive class II anti-HLA antibodies | 432 | 1223 | 28.7 | 360 | 1033 | 28.8 | 72 | 190 | 28.1 | 0.7224 |
Blood group | 3 | 1 | 2 | 0.4660 | ||||||
A | 2018 | 43.0 | 1695 | 43.0 | 323 | 43.4 | ||||
AB | 221 | 4.7 | 178 | 4.5 | 43 | 5.8 | ||||
B | 533 | 11.4 | 448 | 11.4 | 85 | 11.4 | ||||
O | 1916 | 40.9 | 1622 | 41.1 | 294 | 39.5 | ||||
HLA A-B-DR incompatibilities ≥ 4 | 43 | 720 | 15.5 | 34 | 610 | 15.6 | 9 | 110 | 14.9 | 0.6318 |
ABO incompatible transplants | 0 | 1 | 0.1 | 0 | 6 | 0.2 | 0 | 1 | 0.1 | 1.0000 |
Depleting induction | 0 | 2505 | 53.4 | 0 | 2060 | 52.2 | 0 | 445 | 59.6 | 0.0002 |
Maintenance therapy | ||||||||||
Calcineurin inhibitors | 0 | 4611 | 97.9 | 0 | 3873 | 97.8 | 0 | 738 | 98.5 | 0.2240 |
Corticosteroids | 0 | 4832 | 93.0 | 0 | 3683 | 93.0 | 0 | 699 | 93.3 | 0.7775 |
Age ≥ 55 years | 0 | 2435 | 51.9 | 0 | 1984 | 50.3 | 0 | 451 | 60.4 | < 0.0001 |
NA | mean | sd | NA | mean | sd | NA | mean | sd | p-value | |
Waiting list (months) | 108 | 25.9 | 22.7 | 91 | 25.9 | 22.8 | 17 | 25.6 | 21.7 | 0.6865 |
Age (years) | 0 | 53.5 | 13.2 | 0 | 52.9 | 13.5 | 0 | 56.2 | 11.2 | < 0.0001 |
Cold ischemia time (hours) | 18 | 18.1 | 7.4 | 13 | 18.1 | 7.5 | 5 | 18.3 | 7.1 | 0.4490 |