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Table 1 Comparison of baseline characteristics between groups on estimated glomerular filtration rate trajectories. The presence of an episode of rapid deterioration is based on more than 80% of curves displaying this characteristic. The number (percentage) or mean (standard deviation) or median (25th, 75th quartiles) are reported for each subgroup. The median (range) is reported for the number of eGFR measurements

From: Early renal function trajectories, cytomegalovirus serostatus and long-term graft outcomes in kidney transplant recipients

 

Rapid Deterioration

P-value

No (n = 245)

Yes (n = 65)

Age (years)

45.73 ± 12.96

46.65 ± 14.36

0.622

Male

110 (45%)

25 (39%)

0.400

Race,

 White

168 (68.6%)

49 (75.4%)

0.778

 Asian

50 (20.4%)

9 (13.8%)

 Black

15 (6.1%)

4 (6.2%)

 Other

12 (4.9%)

–

BMI (kg/m2)

27.14 (23.44, 30.94)

27.63 (24.00, 31.74)

0.379

Diabetes mellitus

22 (9%)

9 (14%)

0.249

Time on transplant waiting (days)

410 (213–1395)

656 (257–1407)

0.187

IMD

   

 1

92 (37.6%)

21 (32.8%)

 0.825

 2

44 (18.0%)

11 (17.2%)

 3

53 (21.6%

18 (28.1%)

 4

24 (9.8%)

7 (10.9%)

 5

32 (13.1%)

7 (10.9%)

Mean Number of HLA-mismatches

2.80 ± 1.53

2.67 ± 1.37

0.553

NODAT

15 (6.2%)

5 (7.7%)

0.777

Transplant Number

 First

216 (88.2%)

59 (90.8%)

0.720

 Second

21 (8.6%)

6 (9.2%)

 Third

5 (2.0%)

0 (0%)

Donor Type

 Cadaveric

119 (49%)

38 (58%)

0.165

 Live

126 (51%)

27 (42%)

Donor age (years)

44.99 ± 13.29

48.08 ± 13.97

0.110

Male Donor

104 (52%)

31 (54%)

0.765

Donor Race

 White

202 (82.4%)

60 (92.3%)

0.252

 Asian

13 (5.3%)

1 (1.5%)

 Black

26 (10.6%)

3 (4.6%)

 Other

4 (1.6%)

1 (1.5%)

Donor BMI (kg/m2)

25.82 (23.02, 28.50)

25.35 (23.29, 28.56)

0.863

CMV Serostatus Combinations

 D−/R−

69 (28%)

8 (12%)

0.010

 D−/R+

57 (23%)

14 (22%)

 D+/R−

52 (21%)

13 (20%)

 D+/R+

67 (27%)

30 (46%)

CMV D+

124 (50.6)

44 (67.7%)

0.017

CMV R+

119 (48.6%)

43 (66.2%)

0.012

Acute rejection in first year

30 (12.4%)

12 (18.5%)

0.206

Delayed graft function

109 (44.5%)

22 (38.5%)

0.402

Number of eGFR measurements

54 (35.0, 83.5)

54 (39.0, 79.5)

0.929

eGFR (ml/min/1.73 m2)

 3 months

54.63 ± 19.11

54.31 ± 22.27

0.905

 12 months

53.07 ± 20.49

51.92 ± 17.28

0.683

 27 months

51.67 ± 19.52

46.71 ± 15.98

0.091

  1. BMI Body mass index, CMV Cytomegalovirus, D− donor CMV seronegative, D+ Donor CMV seropositive, eGFR Estimated glomerular filtration rate, IMD Index of multiple deprivation, NODAT New onset diabetes after transplantation, R-− Recipient CMV seronegative, R+ Recipient CMV seropositive