| |
2019
|
2020
|
|---|
|
May
|
Jun.
|
Jul.
|
Aug.
|
Sept.
|
Oct.
|
Nov.
|
Dec.
|
Jan.
|
Feb.
|
Mar.
|
Apr.
|
May
|
Jun.
|
Jul.
|
Aug.
|
Sept.
|
|---|
|
Treatment for anemia
|
DARBE
|
DARBE
|
DARBE
|
DARBE
|
DARBE
|
DARBE
|
DARBE
|
DARBE
|
DARBE
|
ROXAD
|
ROXAD
|
ROXAD
|
ROXAD
|
DARBE
|
DARBE
|
DARBE
|
DARBE
|
|
Hemoglobin (g/dL)
|
9.4
|
9.5
|
9.8
|
10.6
|
9.5
|
8.3
|
9.3
|
9.2
|
9.0
|
8.5
|
8.9
|
9.2
|
8.8
|
7.9
|
8.2
|
7.2
|
7.5
|
|
TC (mg/dL)
|
126
|
124
|
115
|
113
|
120
|
110
|
123
|
129
|
127
|
76
|
67
|
64
|
52
|
67
|
122
|
111
|
126
|
|
Non-HDL-C (mg/dL)
|
88
|
—
|
85
|
—
|
87
|
—
|
91
|
—
|
92
|
—
|
49
|
47
|
33
|
43
|
85
|
80
|
92
|
|
HDL-C (mg/dL)
|
30
|
—
|
30
|
—
|
33
|
—
|
32
|
—
|
36
|
—
|
18
|
17
|
19
|
24
|
37
|
31
|
34
|
|
AST (IU/L)
|
18
|
17
|
16
|
18
|
17
|
17
|
22
|
19
|
7
|
18
|
19
|
20
|
17
|
19
|
18
|
17
|
17
|
|
ALT (IU/L)
|
8
|
8
|
8
|
8
|
8
|
8
|
9
|
8
|
8
|
9
|
8
|
10
|
9
|
9
|
7
|
7
|
7
|
|
Serum albumin (g/dL)
|
3.6
|
3.5
|
3.3
|
3.4
|
3.4
|
3.3
|
3.5
|
3.5
|
3.4
|
3.0
|
3.1
|
3.4
|
3.4
|
3.2
|
3.5
|
3.2
|
3.4
|
|
BUN (mg/dL)
|
36.3
|
54.3
|
52.2
|
58.0
|
47.8
|
61.2
|
55.5
|
60.5
|
48.6
|
57.4
|
48.3
|
51.6
|
50.9
|
40.8
|
39.4
|
43.8
|
54.2
|
|
Creatinine (mg/dL)
|
8.9
|
8.9
|
9.7
|
9.8
|
9.6
|
9.7
|
9.6
|
9.2
|
9.5
|
8.2
|
8.1
|
7.6
|
7.2
|
6.5
|
7.0
|
8.0
|
8.9
|
|
CRP (mg/dL)
|
0.27
|
0.68
|
0.22
|
0.13
|
0.37
|
0.38
|
0.28
|
0.19
|
0.24
|
0.43
|
0.30
|
0.25
|
0.23
|
0.28
|
0.21
|
0.35
|
0.15
|
|
Ferritin (ng/ml)
|
—
|
120.4
|
—
|
—
|
420.3
|
—
|
—
|
339.7
|
—
|
361.8
|
324.0
|
219.3
|
193.8
|
215.6
|
238.2
|
178.7
|
173.8
|
|
TSAT (%)
|
27.5
|
24.0
|
21.8
|
30.2
|
30.4
|
45.5
|
32.3
|
44.5
|
50.9
|
56.2
|
82.4
|
41.8
|
57.1
|
39.3
|
40.8
|
26.8
|
28.3
|
|
BMI (kg/m2)
|
22.1
|
22.0
|
21.9
|
21.9
|
22.1
|
22.1
|
22.2
|
22.4
|
22.4
|
22.4
|
22.2
|
21.9
|
21.9
|
21.8
|
21.6
|
21.8
|
21.5
|
|
Pulse rate (ppm)
|
64.1
|
69.6
|
65.5
|
67.4
|
69.5
|
65.4
|
68.5
|
67.1
|
67.4
|
71.8
|
71.7
|
73.4
|
69.9
|
68.6
|
67.5
|
65.6
|
63.8
|
|
SBP (mmHg)
|
146.3
|
153.3
|
149.6
|
139.7
|
140.4
|
138.7
|
147.2
|
141.2
|
144.5
|
150.3
|
162.7
|
160.0
|
153.8
|
151.4
|
154.0
|
151.2
|
148.0
|
|
DBP (mmHg)
|
70.0
|
76.2
|
72.3
|
68.5
|
69.5
|
69.3
|
71.2
|
66.6
|
69.0
|
74.4
|
78.4
|
73.1
|
70.2
|
71.4
|
71.6
|
71.5
|
68.2
|
- Treatment for renal anemia was switched from darbepoetin alfa to roxadustat. The treatment with roxadustat was done from February 2 to June 12, 2020. Measurements were done in the last week of each month. Note the reductions of TC, Non-HDL-C, and HDL-C levels during roxadustat treatment.
- Abbreviations: DARBE darbepoetin alfa; ROXAD roxadustat; TC total cholesterol; Non-HDL-C non-high-density lipoprotein cholesterol; HDL-C high-density lipoprotein cholesterol; AST aspartate aminotransferase; ALTalanine aminotransferase; BUN blood urea nitrogen; CRP C-reactive protein; TSAT transferrin saturation; BMI body mass index; SBP systolic blood pressure; DBP diastolic blood pressure
