Table 2 Routine laboratory tests, vital signs, and body mass index before, during, and after roxadustat treatment
| Â | 2019 | 2020 | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
May | Jun. | Jul. | Aug. | Sept. | Oct. | Nov. | Dec. | Jan. | Feb. | Mar. | Apr. | May | Jun. | Jul. | Aug. | Sept. | |
Treatment for anemia | DARBE | DARBE | DARBE | DARBE | DARBE | DARBE | DARBE | DARBE | DARBE | ROXAD | ROXAD | ROXAD | ROXAD | DARBE | DARBE | DARBE | DARBE |
Hemoglobin (g/dL) | 9.4 | 9.5 | 9.8 | 10.6 | 9.5 | 8.3 | 9.3 | 9.2 | 9.0 | 8.5 | 8.9 | 9.2 | 8.8 | 7.9 | 8.2 | 7.2 | 7.5 |
TC (mg/dL) | 126 | 124 | 115 | 113 | 120 | 110 | 123 | 129 | 127 | 76 | 67 | 64 | 52 | 67 | 122 | 111 | 126 |
Non-HDL-C (mg/dL) | 88 | — | 85 | — | 87 | — | 91 | — | 92 | — | 49 | 47 | 33 | 43 | 85 | 80 | 92 |
HDL-C (mg/dL) | 30 | — | 30 | — | 33 | — | 32 | — | 36 | — | 18 | 17 | 19 | 24 | 37 | 31 | 34 |
AST (IU/L) | 18 | 17 | 16 | 18 | 17 | 17 | 22 | 19 | 7 | 18 | 19 | 20 | 17 | 19 | 18 | 17 | 17 |
ALT (IU/L) | 8 | 8 | 8 | 8 | 8 | 8 | 9 | 8 | 8 | 9 | 8 | 10 | 9 | 9 | 7 | 7 | 7 |
Serum albumin (g/dL) | 3.6 | 3.5 | 3.3 | 3.4 | 3.4 | 3.3 | 3.5 | 3.5 | 3.4 | 3.0 | 3.1 | 3.4 | 3.4 | 3.2 | 3.5 | 3.2 | 3.4 |
BUN (mg/dL) | 36.3 | 54.3 | 52.2 | 58.0 | 47.8 | 61.2 | 55.5 | 60.5 | 48.6 | 57.4 | 48.3 | 51.6 | 50.9 | 40.8 | 39.4 | 43.8 | 54.2 |
Creatinine (mg/dL) | 8.9 | 8.9 | 9.7 | 9.8 | 9.6 | 9.7 | 9.6 | 9.2 | 9.5 | 8.2 | 8.1 | 7.6 | 7.2 | 6.5 | 7.0 | 8.0 | 8.9 |
CRP (mg/dL) | 0.27 | 0.68 | 0.22 | 0.13 | 0.37 | 0.38 | 0.28 | 0.19 | 0.24 | 0.43 | 0.30 | 0.25 | 0.23 | 0.28 | 0.21 | 0.35 | 0.15 |
Ferritin (ng/ml) | — | 120.4 | — | — | 420.3 | — | — | 339.7 | — | 361.8 | 324.0 | 219.3 | 193.8 | 215.6 | 238.2 | 178.7 | 173.8 |
TSAT (%) | 27.5 | 24.0 | 21.8 | 30.2 | 30.4 | 45.5 | 32.3 | 44.5 | 50.9 | 56.2 | 82.4 | 41.8 | 57.1 | 39.3 | 40.8 | 26.8 | 28.3 |
BMI (kg/m2) | 22.1 | 22.0 | 21.9 | 21.9 | 22.1 | 22.1 | 22.2 | 22.4 | 22.4 | 22.4 | 22.2 | 21.9 | 21.9 | 21.8 | 21.6 | 21.8 | 21.5 |
Pulse rate (ppm) | 64.1 | 69.6 | 65.5 | 67.4 | 69.5 | 65.4 | 68.5 | 67.1 | 67.4 | 71.8 | 71.7 | 73.4 | 69.9 | 68.6 | 67.5 | 65.6 | 63.8 |
SBP (mmHg) | 146.3 | 153.3 | 149.6 | 139.7 | 140.4 | 138.7 | 147.2 | 141.2 | 144.5 | 150.3 | 162.7 | 160.0 | 153.8 | 151.4 | 154.0 | 151.2 | 148.0 |
DBP (mmHg) | 70.0 | 76.2 | 72.3 | 68.5 | 69.5 | 69.3 | 71.2 | 66.6 | 69.0 | 74.4 | 78.4 | 73.1 | 70.2 | 71.4 | 71.6 | 71.5 | 68.2 |