Table 1 Baseline demographic data; Mean (Standard deviation (SD)), number (n) or percentage (%) for the total for all of group 1 and unblinded data for the two randomised arms; uACR/uPCR = urinary albumin/protein:creatinine ratio. eGFR = Estimated glomerular filtration rate; CRP = C-Reactive Protein. 6MWT = Six-minute walk test. MLHF = Minnesota Living and Heart Failure Questionnaire. Electrocardiogram (ECG): N = Within normal limits; NCS = Abnormal and not clinically significant; ACS = Abnormal and clinically significant. FDI = Ferric Derisomaltose

Age (years) (SD)

59.6 (11.7)

61.6 (10.1)

57.8 (12.9)

Range

32–78

37–78

32–78

 Male

26 (49%)

11 (42.3%)

15 (53.6%)

 Female

27 (51%)

14 (53.8%)

13 (46.4%)

 Unknown

1

1

0

 White

42 (78%)

19 (73.1%)

23 (82.1%)

 Asian

3 (5%)

1 (3.8%)

2 (7.1%)

 Black

7 (13%)

4 (15.4%)

3 (10.7%)

 Mixed Race

1 (2%)

1 (3.8%)

0 (0%)

 Unknown/other

1 (2%)

1 (3.8%)

0 (0%)

 Yes; current

5 (9%)

1 (3.8%)

4 (14.3%)

 Yes; previous

17 (32%)

8 (30.8%)

9 (32.1%)

 No

32 (59%)

17 (65.4%)

15 (53.6%)

Body Mass Index (BMI)

30.3 (6.5), 53

30.7 (6.8)

30.01 (6.4)

Serum Ferritin (SF) (microg/L)

66.3

(44.1)

53

64.2

(29.1)

26

68.4

(55.3)

27

Transferrin Saturation % (TSAT)

20.1 (7.4)

53

22.3 (8.8)

26

19.7 (5.6)

27

Haemoglobin (Hb) (g/L)

128.7

(10.1), 54

131

(7.4), 26

126.6

(11.8), 28

Serum Creatinine (micromol/L)

186.7

(58.6), 54

167

(40.2), 26

204.9

(67.3), 28

eGFR (ml/min/1.73m²)

31.1

(9.6), 54

33.2

(9.3), 26

29.1

(9.6), 28

Cystatin C

2.2

(0.6), 52

2.1

(0.5), 26

2.4

(0.6), 26

uACR (mg/mmol)

60.9

(133.3), 26

26.9

(40), 13

94.8

(181.4), 13

uPCR (mg/mmol)

83.8

(128.4), 40

51.9

(59.3), 19

112.7

(164.8), 21

CRP

(mg/L)

5.0

(4.4), 53

6.3

(5.5), 26

3.8

(2.4), 27

Serum Albumin (g/L)

39.8

(5.6)

40.8

(4.2)

38.8

(6.9)

Platelet count

(X10⁵)

235

(58.9)

226

(52.4)

243

(64.1)

Phosphate

(mmol/L)

1.2

(0.2)

1.1

(0.2)

1.2

(0.2)

NT pro BNP

(ng/L)

485.2

(1268.4), 51

422.5 (881.9), 25

545.4 (1569.5), 26

PWV measurement

8.3

(3.2), 54

8.3

(2.8), 26

8.3

(3.6), 28

AiX measurement

24.2 (10.7)

54

25.4 (10.7)

26

24.1 (10.8)

28

6MWT

Metres (m)

401.2

(120.2), 52

386.6

(135.8), 25

414.7

(104.5), 27

KD-KQoL SF36

(normalised data)

40.2

(10.4), 48

40.2

(10.4), 21

40.4

(9.55), 27

MLHF

23.97

(26.3)

22.7 (25.7)

18

25.0 (27.3)

24

Systolic Blood Pressure

(mmHG)

133.6

(19.5), 54

138.2 (19.9), 26

129.4

(18.4), 28

Diastolic Blood Pressure

(mmHG)

77.3

(11.3), 54

78.5

(10.7), 26

76.2

(11.8), 28

 N

38

17

21

 NCS

13

8

5

 ACL

1

1

0

 Not Recorded

2

0

2

 Diabetes

17

8

9

 Hypertension

4

2

2

 Polycystic Kidney Disease

5

2

3

 Pyelonephritis/Reflux

3

1

2

 Glomerulonephritis / IgA/vasculitis/interstitial nephritis

14

8

6

 Other/unknown

11

5

6