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Table 1 Baseline demographic data; Mean (Standard deviation (SD)), number (n) or percentage (%) for the total for all of group 1 and unblinded data for the two randomised arms; uACR/uPCR = urinary albumin/protein:creatinine ratio. eGFR = Estimated glomerular filtration rate; CRP = C-Reactive Protein. 6MWT = Six-minute walk test. MLHF = Minnesota Living and Heart Failure Questionnaire. Electrocardiogram (ECG): N = Within normal limits; NCS = Abnormal and not clinically significant; ACS = Abnormal and clinically significant. FDI = Ferric Derisomaltose

From: A multicentre prospective double blinded randomised controlled trial of intravenous iron (ferric Derisomaltose (FDI)) in Iron deficient but not anaemic patients with chronic kidney disease on functional status

Group and number of participants FDI or Placebo
n = 54
CKD, no anaemia but iron deficiency
FDI
n = 26
Placebo
N = 28
Age (years) (SD) 59.6 (11.7) 61.6 (10.1) 57.8 (12.9)
Range 32–78 37–78 32–78
Sex
 Male 26 (49%) 11 (42.3%) 15 (53.6%)
 Female 27 (51%) 14 (53.8%) 13 (46.4%)
Unknown 1 1 0
Ethnicity
 White 42 (78%) 19 (73.1%) 23 (82.1%)
 Asian 3 (5%) 1 (3.8%) 2 (7.1%)
 Black 7 (13%) 4 (15.4%) 3 (10.7%)
 Mixed Race 1 (2%) 1 (3.8%) 0 (0%)
 Unknown/other 1 (2%) 1 (3.8%) 0 (0%)
Smoker
 Yes; current 5 (9%) 1 (3.8%) 4 (14.3%)
 Yes; previous 17 (32%) 8 (30.8%) 9 (32.1%)
 No 32 (59%) 17 (65.4%) 15 (53.6%)
Body Mass Index (BMI) 30.3 (6.5), 53 30.7 (6.8) 30.01 (6.4)
Serum Ferritin (SF) (microg/L) 66.3
(44.1)
53
64.2
(29.1)
26
68.4
(55.3)
27
Transferrin Saturation % (TSAT) 20.1 (7.4)
53
22.3 (8.8)
26
19.7 (5.6)
27
Haemoglobin (Hb) (g/L) 128.7
(10.1), 54
131
(7.4), 26
126.6
(11.8), 28
Serum Creatinine (micromol/L) 186.7
(58.6), 54
167
(40.2), 26
204.9
(67.3), 28
eGFR (ml/min/1.73m2) 31.1
(9.6), 54
33.2
(9.3), 26
29.1
(9.6), 28
Cystatin C 2.2
(0.6), 52
2.1
(0.5), 26
2.4
(0.6), 26
uACR (mg/mmol) 60.9
(133.3), 26
26.9
(40), 13
94.8
(181.4), 13
uPCR (mg/mmol) 83.8
(128.4), 40
51.9
(59.3), 19
112.7
(164.8), 21
CRP
(mg/L)
5.0
(4.4), 53
6.3
(5.5), 26
3.8
(2.4), 27
Serum Albumin (g/L) 39.8
(5.6)
40.8
(4.2)
38.8
(6.9)
Platelet count
(X105)
235
(58.9)
226
(52.4)
243
(64.1)
Phosphate
(mmol/L)
1.2
(0.2)
1.1
(0.2)
1.2
(0.2)
NT pro BNP
(ng/L)
485.2
(1268.4), 51
422.5 (881.9), 25 545.4 (1569.5), 26
PWV measurement 8.3
(3.2), 54
8.3
(2.8), 26
8.3
(3.6), 28
AiX measurement 24.2 (10.7)
54
25.4 (10.7)
26
24.1 (10.8)
28
6MWT
Metres (m)
401.2
(120.2), 52
386.6
(135.8), 25
414.7
(104.5), 27
KD-KQoL SF36
(normalised data)
40.2
(10.4), 48
40.2
(10.4), 21
40.4
(9.55), 27
MLHF 23.97
(26.3)
22.7 (25.7)
18
25.0 (27.3)
24
Systolic Blood Pressure
(mmHG)
133.6
(19.5), 54
138.2 (19.9), 26 129.4
(18.4), 28
Diastolic Blood Pressure
(mmHG)
77.3
(11.3), 54
78.5
(10.7), 26
76.2
(11.8), 28
Baseline ECG
N 38 17 21
NCS 13 8 5
ACL 1 1 0
Not Recorded 2 0 2
Diabetes 17 8 9
Hypertension 4 2 2
Polycystic Kidney Disease 5 2 3
Pyelonephritis/Reflux 3 1 2
Glomerulonephritis / IgA/vasculitis/interstitial nephritis 14 8 6
Other/unknown 11 5 6