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Table 1 Clinical characteristics of the study patients, according to stages of CKD

From: Hyperphosphatemia with elevated serum PTH and FGF23, reduced 1,25(OH)2D and normal FGF7 concentrations characterize patients with CKD

Characteristics Estimated GFR (mL/min/1.73 m2)
≥ 60 (n= 31) 45–59 (n= 16) 30–44 (n= 11) 15–29 (n= 15) < 15 (n= 12)
Age (yr) 51.1 ± 17.2 60.2 ± 15.3 60.4 ± 14.9 63.6 ± 16.5 67.1 ± 12.0
Female sex (no. [%]) 21 (67.7) 9 (56.3) 7 (63.6) 8 (53.3) 4 (33.3)
Diabetes (no. [%]) 6 (19.4) 5 (31.3) 4 (36.4) 4 (26.7) 5 (41.7)
Calcium use (no. [%]) 8 (25.8) 4 (25.0) 2 (18.2) 4 (26.7) 4 (33.3)
Cholecalciferol or ergocalciferol use (no. [%]) 13 (41.9) 6 (37.5) 3 (27.3) 4 (26.7) 6 (50)
Body mass index (kg/m2) 28.1 ± 6.0 26.7 ± 6.1 27.8 ± 5.7 29.5 ± 6.3 32.2 ± 9.2
Systolic blood pressure (mmHg) 120.9 ± 13.7 127.7 ± 16.8 122.6 ± 21.6 125.7 ± 11.7 135.5 ± 16.0
Hemoglobin (g/dL) 12.6 ± 1.4 11.9 ± 1.7 11.5 ± 1.0 11.0 ± 2.0 10.6 ± 1.2
Fasting plasma glucose (mg/dL) 109 ± 23 113 ± 32 109 ± 20 117 ± 30 124 ± 42
Blood urea nitrogen (mg/dL) 16.4 ± 4.6 21.3 ± 5.4 24.9 ± 7.4 44.5 ± 8.5 54.4 ± 14.4
Estimated GFR (mL/min/1.73 m2) 88.1 ± 17.3 51.4 ± 4.8 37.1 ± 3.2 23.7 ± 4.4 12.8 ± 1.5
Serum sodium (mEq/L) 140.4 ± 2.9 140.8 ± 1.7 140.2 ± 2.5 140.5 ± 2.4 141.4 ± 2.8
Serum potassium (mEq/L) 4.2 ± 0.5 4.6 ± 0.4 4.4 ± 0.4 4.5 ± 0.6 4.6 ± 0.3
Serum chloride (mEq/L) 103.1 ± 3.0 103.9 ± 1.7 104.9 ± 4.6 104.3 ± 3.1 103.7 ± 5.8
Serum bicarbonate (mEq/L) 24.5 ± 2.0 24.0 ± 1.4 22.1 ± 2.5 23.7 ± 4.4 21.9 ± 2.9
Corrected serum calcium (mg/dL)a 9.5 ± 0.5 9.4 ± 0.4 9.4 ± 0.5 9.4 ± 0.4 9.3 ± 0.5
Serum phosphate (mg/dL) 3.3 ± 0.4 3.3 ± 0.7 3.5 ± 0.6 4.0 ± 0.6 4.7 ± 0.3
Serum alkaline phosphatase (U/L)b 85 (61–100) 58 (52–91) 64 (53–80) 104 (70–112) 92 (76–116)
24-hour urine protein (mg/day)b 227 (147–377) 185 (135–410) 287 (252–502) 611 (347-2,327) 2561 (1554–4208)
Serum parathyroid hormone (pg/mL)b 63 (47–85) 66 (45–83) 72 (46–93) 115 (92–168) 246 (143–393)
Serum 25(OH)D (ng/mL) 38.8 ± 11.9 49.9 ± 12.3 37.1 ± 11.9 42.2 ± 13.0 41.8 ± 15.7
Serum 1,25(OH)2D (pg/mL) 41.5 ± 12.7 33.5 ± 12.5 29.8 ± 11.6 21.7 ± 8.4 15.6 ± 1.8
Serum intact FGF7 (pg/mL)b 46.1
(39.2–56.9)
43.1
(39.0-51.5)
47.3
(38.3–66.5)
47.7
(37.7–55.8)
49.6
(42.5–65.6)
Serum intact FGF23 (pg/mL)b 41.9
(33.0-52.7)
56.4
(46.9–60.2)
62.9
(50.9–79.3)
117.5
(88.4-156.6)
415.9
(278.3-500.9)
  1. For continuous variables, mean ± SD; for categorical variables, n (%); unless otherwise specified
  2. aCorrected serum calcium (mg/dL) = measured total calcium (mg/dL) + 0.8(4.0 – serum albumin (g/dL))
  3. bShown as median (interquartile range, 25–75 %)