Table 2 Proportional hazards analysis of 5-year association of death or cardiovascular event with cardiovascular risk factors alone, with KCD20 alone, and with KCD20 together with cardiovascular risk factors

 KCD20

1.44 (1.19, 1.74)

0.0004

 Age (years)

1.07 (1.05, 1.08)

< 0.0001

1.07 (1.05, 1.08)

< 0.0001

 Male sex

1.63 (1.35, 1.97)

< 0.0001

1.63 (1.35, 1.97)

< 0.0001

 Systolic blood pressure (per 10 mmHg)

1.05 (1.00, 1.11)

0.037

1.06 (1.01, 1.11)

0.028

 Antihypertensive medication

0.93 (0.70, 1.22)

0.58

0.89 (0.68, 1.18)

0.43

 Diabetes

1.56 (1.29, 1.90)

< 0.0001

1.54 (1.27, 1.87)

< 0.0001

 Log₂(body mass index, kg/m²)

1.80 (1.23, 2.65)

0.0026

1.74 (1.18, 2.56)

0.0050

 Myocardial infarction

0.96 (0.74, 1.24)

0.74

0.96 (0.74, 1.24)

0.74

 Coronary revascularisation

1.75 (1.40, 2.19)

< 0.0001

1.75 (1.40, 2.19)

< 0.0001

 Previous stroke or transient ischaemic attack

1.29 (1.01, 1.65)

0.041

1.27 (1.00, 1.63)

0.053

 Peripheral vascular disease

1.51 (1.06, 2.16)

0.022

1.50 (1.05, 2.13)

0.025

 Atrial fibrillation/flutter

1.62 (1.29, 2.03)

< 0.0001

1.64 (1.31, 2.06)

< 0.0001

 Current or former smoker

1.21 (1.02, 1.44)

0.029

1.22 (1.03, 1.45)

0.023

 KCD20

1.31 (1.08, 1.60)

0.0076