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Table 4 Time-dependent receiver operating characteristic curve analysis of identification of individuals who experienced death or cardiovascular event by cardiovascular risk factors, by KCD20, eGFRstep or eGFR60 alone, and by the combination of cardiovascular risk factors and KCD20, eGFRstep or eGFR60

From: Kidney age - chronological age difference (KCD) score provides an age-adapted measure of kidney function

Model

AUC (95% CI)

Cardiovascular risk factors alone

0.717 (0.694, 0.740)a

KCD20 alone

0.531 (0.512, 0.550)b

eGFRstep alone

0.523 (0.510, 0.537)b

eGFR60 alone

0.561 (0.541, 0.581)b

Cardiovascular risk factors and KCD20

0.719 (0.696, 0.742)a

Cardiovascular risk factors and eGFRstep

0.718 (0.695, 0.741)a

Cardiovascular risk factors and eGFR60

0.718 (0.695, 0.741)a

  1. AUC area under the curve calculated from time-dependent receiver operating characteristic curve analysis for 5-year follow-up [32], CI confidence interval, eGFR60 eGFR < 60 ml/min/1.73 m2, eGFRstep age-dependent stepped eGFR criteria of Delanaye et al. [10], KCD20 Kidney age-Chronological age Difference score ≥ 20 years
  2. The model with cardiovascular risk factors alone included age, sex, previous myocardial infarction, coronary revascularisation, stroke or transient ischaemic attack, peripheral vascular disease, diabetes, atrial fibrillation, log2(BMI), systolic blood pressure, antihypertensive medication, and smoking status on enrolment
  3. aThere were no statistically significant differences between AUC for the model with cardiovascular risk factors alone, and the models with cardiovascular risk factors and KCD20, eGFRstep, or eGFR60
  4. bAUC for eGFR60 alone was higher than for KCD20 alone (P < 0.0001) and for eGFRstep alone (P = 0.0001), with no statistically significant difference between AUC for KCD20 alone and for eGFRstep alone (P = 0.31)