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Table 1 Baseline characteristics of the cohort

From: C-terminal and intact FGF23 in kidney transplant recipients and their associations with overall graft survival

Variables

All patients (n = 562)

Death/graft loss (n = 94)

No event (n = 468)

P

Age at study entry (years)

54.6 (44.5–66.9)

62.5 (54.0–71.6)

53.4 (43.0–64.2)

< 0.0001

Male, n (%)

345 (61.4%)

68 (72.3%)

227 (59.2%)

0.017

Primary kidney diseases, n (%)

0.888

 Glomerulonephritis

228 (40.6%)

38 (40.4%)

190 (40.6%)

 

 Tubulointerstitial disease

54 (9.6)

9 (9.6%)

45 (9.6%)

 

 Polycystic renal disease

70 (12.5%)

10 (10.6%)

60 (12.8%)

 

 Dysplasia and hypoplasia

8 (1.4%)

1 (1.1%)

7 (1.5%)

 

 Diabetic nephropathy

18 (3.2%)

3 (3.2%)

15 (3.2%)

 

 Hypertensive nephropathy

16 (2.8%)

2 (2.1%)

14 (3.0%)

 

 Other or unknown cause

168 (29.9)

31 (33.0%)

137 (29.3%)

 

Time post-transplantation (years)

5.89 (2.90–10.48)

6.93 (3.65–12.23)

5.69 (2.88–10.37)

0.063

Time on dialysis (month)

46.0 (19.0–75.0)

50.0 (21.5–73.5)

44.0 (19.0–76.0)

0.503

Donor age (years)

51.0 (40.0–61.0)

54.0 (42.0–68.0)

50.0 (39.0–59.0)

0.013

Cold ischemia time (hours)

8.51 (3.24–14.04)

9.92 (6.42–18.16)

8.18 (3.02–13.73)

0.023

Hemoglobin (g/dl)

12.71 ± 1.76

12.20 ± 1.78

12.81 ± 1.74

0.002

Serum albumin (g/dl)

4.55 ± 0.35

4.46 ± 0.36

4.57 ± 0.35

0.04

Total cholesterol (mg/dl)

217.0 (186.0–254.0)

210.0 (171.5–247.3)

218.0 (187.0–254.8)

0.221

Serum creatinine (mg/dl)

1.57 (1.26–2.06)

2.23 (1.42–3.02)

1.52 (1.24–1.94)

< 0.0001

eGFR (mL/min/1.73 m2)

43.0 (31.0–58.0)

30.0 (21.0–50.5)

44.5 (34.0–58.0)

< 0.0001

Serum calcium (mmol/L)

2.47 (2.37–2.59)

2.42 (2.33–2.57)

2.48 (2.39–2.59)

0.014

Serum phosphorus (mmol/L)

0.86 (0.71–1.02)

0.99 (0.77–1.23)

0.84 (0.69–0.98)

< 0.0001

Parathyroid hormone (pg/ml)

79.18 (49.91–133.70)

104.9 (58.76–206.3)

76.34 (49.06–126.60)

0.002

Intact FGF23 (pg/ml)

30.94 (15.43–68.98)

45.24 (18.63–159.0)

29.04 (15.23–60.65)

0.002

C terminal FGF23 (pg/ml)

12.57 (6.38–27.38)

24.59 (11.43–87.82)

10.67 (5.99–22.73)

< 0.0001

Urinary protein excretion (mg/24 h)

163.0 (99.0–306.5)

265.5 (129.5–691.5)

153.0 (96.0–274.0)

0.0001

  1. Data are given as median (interquartile ranges) or number (%). Baseline characteristics of the study population. Patients were followed for graft loss and all-cause mortality for a follow-up of 48 months. The composite end-point (event) was defined as graft loss or death due to any reason
  2. eGFR estimated glomerular filtration rate