Effect of various dialysis modalities on intradialytic hemodynamics, tissue injury and patient discomfort in chronic dialysis patients: design of a randomized cross-over study (HOLLANT)

Table 1 Inclusion and exclusion criteria

Inclusion criteria
- Patients treated with HD or HDF 3 x per week during at least 4 h for at least 2 months.
- Ability to understand study procedures.
- Willingness to provide informed consent.
- Dialysis single-pool Kt/V for urea (spKt/Vurea) ≥ 1.2^a
- Achievement of a blood flow of ≥350 ml/min and/or convection volume of ≥23 Liter per treatment during the run-in phase.
- Dialysis access recirculation < 10%^a.
Exclusion criteria
- Age < 18 years.
- Life expectancy < 3 months.
- Participation in another clinical intervention trial.
- Severe incompliance to the dialysis procedure and accompanying prescriptions.

^aBased on the most recent (before start of the study) measurements from daily practice, in accordance with the applicable national and international guidelines [47, 48]

ISSN: 1471-2369