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Table 3 The prevalence of PLA2R, IgG4 and staining intensity assessed by IHC in MN patients

From: A cohort study of membranous nephropathy, primary or secondary

   Primary MN (n = 79) Secondary MN (n = 29) p value
Glomerular PLA2R Ag expression Positive 76 (96.2%) 1 (3.5%) <0.001
Negative 3 (3.8%) 28 (96.5%)  
Staining intensitya Moderate 29 (38.2%) - -
severe 47 (61.8%) 1 (100%)  
Glomerular IgG4 expression Positive 68 (86.1%) 3 (10.3%) <0.001
Negative 11 (13.9%) 26 (89.7%)  
  1. Abbreviations: MN membranous nephropathy, PLA2R phospholipase A2 receptor, IgG4 Immunoglobulin G4
  2. aIHC staining for those cases with very weak positivity were considered as negative
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