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Table 3 The prevalence of PLA2R, IgG4 and staining intensity assessed by IHC in MN patients

From: A cohort study of membranous nephropathy, primary or secondary

Ā Ā 

Primary MN (n = 79)

Secondary MN (n = 29)

p value

Glomerular PLA2R Ag expression

Positive

76 (96.2%)

1 (3.5%)

<0.001

Negative

3 (3.8%)

28 (96.5%)

Ā 

Staining intensitya

Moderate

29 (38.2%)

-

-

severe

47 (61.8%)

1 (100%)

Ā 

Glomerular IgG4 expression

Positive

68 (86.1%)

3 (10.3%)

<0.001

Negative

11 (13.9%)

26 (89.7%)

Ā 
  1. Abbreviations: MN membranous nephropathy, PLA2R phospholipase A2 receptor, IgG4 Immunoglobulin G4
  2. aIHC staining for those cases with very weak positivity were considered as negative