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Fig. 4 | BMC Nephrology

Fig. 4

From: Comprehensive analysis of IgA nephropathy expression profiles: identification of potential biomarkers and therapeutic agents

Fig. 4

Multilayer regulatory network (a), and its derived sub-networks showing top regulatory molecules and their targets (b-d). a: Multilayer regulatory network comprising of the intersecting mRNAs (DEGs), DEmiRs, and their related TFs and lncRNAs. The constituents of this multilayer network are including 46 transcription factors (green circle), 132 DEmiRs (yellow circle), 217 LncRNAs (magenta circle), and 598 DEGs (blue circle). The DEmiRs and DEGs with no interactions are omitted from the network. b: Top miRNA molecule (miR-124) (in case of degree centrality and log2FC in the DEmiR dataset), c: top lncRNA (HOTAIR), (D): top transcription factor (NF-κB) and their interactions. *DEGs, DEmiRs, lncRNAs and TFs are colored in blue, yellow, violet and green, respectively. The multilayer regulatory network is accessible at network data exchange (NDEx) server by the below link: [https://public.ndexbio.org/#/network/a1d9669e-7daf-11eb-9e72-0ac135e8bacf?accesskey=c229bf52538f314edd2617ce1f6c6e6cd81ebcbef1437c6d7c81167c3590d973]

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